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Research ArticleCEREBRAL CAVERNOUS MALFORMATION
Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation
- Alan T. Tang1,
- Katie R. Sullivan1,
- Courtney C. Hong1,
- Lauren M. Goddard1,
- Aparna Mahadevan1,
- Aileen Ren1,
- Heidy Pardo2,
- Amy Peiper2,
- Erin Griffin2,
- Ceylan Tanes3,
- Lisa M. Mattei3,
- Jisheng Yang1,
- Li Li1,
- Patricia Mericko-Ishizuka1,
- Le Shen4,
- Nicholas Hobson4,
- Romuald Girard4,
- Rhonda Lightle4,
- Thomas Moore4,
- Robert Shenkar4,
- Sean P. Polster4,
- Claudia J. Roedel5,
- Ning Li6,
- Qin Zhu7,
- Kevin J. Whitehead8,
- Xiangjian Zheng9,10,
- Amy Akers11,
- Leslie Morrison12,
- Helen Kim13,
- Kyle Bittinger3,
- Christopher J. Lengner6,14,15,
- Markus Schwaninger16,
- Anna Velcich17,
- Leonard Augenlicht17,
- Salim Abdelilah-Seyfried5,18,
- Wang Min19,
- Douglas A. Marchuk2,
- Issam A. Awad4 and
- Mark L. Kahn1,*
- 1Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.
- 2Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.
- 3Division of Gastroenterology, Hepatology, and Nutrition, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
- 4Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA.
- 5Institute for Biochemistry and Biology, Department of Animal Physiology, Potsdam University, Karl-Liebknecht-Str. 24-25, Haus 26, 14476 Potsdam, Germany.
- 6Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 7Graduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 8Division of Cardiovascular Medicine and the Program in Molecular Medicine, University of Utah, Salt Lake City, UT 84112, USA.
- 9Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
- 10Centenary Institute, Sydney Medical School, University of Sydney, Sydney, NSW 2050, Australia.
- 11Angioma Alliance, Norfolk, VA 23517, USA.
- 12Department of Neurology and Pediatrics, University of New Mexico, Albuquerque, NM 87106, USA.
- 13Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA.
- 14Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 15Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- 16Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, 23562 Lübeck, Germany.
- 17Department of Cell Biology, Albert Einstein College of Medicine/Albert Einstein Cancer Center, NY 10461, USA.
- 18Institute of Molecular Biology, Hannover Medical School, Carl-Neuberg Str. 1, D-30625 Hannover, Germany.
- 19Department of Pathology and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06510, USA.
- ↵*Corresponding author. Email: markkahn{at}pennmedicine.upenn.edu
See allHide authors and affiliations
Science Translational Medicine 27 Nov 2019:
Vol. 11, Issue 520, eaaw3521
DOI: 10.1126/scitranslmed.aaw3521
Vol. 11, Issue 520, eaaw3521
DOI: 10.1126/scitranslmed.aaw3521
Alan T. Tang
Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.
Katie R. Sullivan
Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.
Courtney C. Hong
Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.
Lauren M. Goddard
Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.
Aparna Mahadevan
Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.
Aileen Ren
Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.
Heidy Pardo
Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.
Amy Peiper
Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.
Erin Griffin
Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.
Ceylan Tanes
Division of Gastroenterology, Hepatology, and Nutrition, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Lisa M. Mattei
Division of Gastroenterology, Hepatology, and Nutrition, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Jisheng Yang
Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.
Li Li
Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.
Patricia Mericko-Ishizuka
Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.
Le Shen
Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA.
Nicholas Hobson
Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA.
Romuald Girard
Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA.
Rhonda Lightle
Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA.
Thomas Moore
Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA.
Robert Shenkar
Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA.
Sean P. Polster
Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA.
Claudia J. Roedel
Institute for Biochemistry and Biology, Department of Animal Physiology, Potsdam University, Karl-Liebknecht-Str. 24-25, Haus 26, 14476 Potsdam, Germany.
Ning Li
Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Qin Zhu
Graduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kevin J. Whitehead
Division of Cardiovascular Medicine and the Program in Molecular Medicine, University of Utah, Salt Lake City, UT 84112, USA.
Xiangjian Zheng
Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.Centenary Institute, Sydney Medical School, University of Sydney, Sydney, NSW 2050, Australia.
Amy Akers
Angioma Alliance, Norfolk, VA 23517, USA.
Leslie Morrison
Department of Neurology and Pediatrics, University of New Mexico, Albuquerque, NM 87106, USA.
Helen Kim
Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA.
Kyle Bittinger
Division of Gastroenterology, Hepatology, and Nutrition, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Christopher J. Lengner
Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Markus Schwaninger
Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, 23562 Lübeck, Germany.
Anna Velcich
Department of Cell Biology, Albert Einstein College of Medicine/Albert Einstein Cancer Center, NY 10461, USA.
Leonard Augenlicht
Department of Cell Biology, Albert Einstein College of Medicine/Albert Einstein Cancer Center, NY 10461, USA.
Salim Abdelilah-Seyfried
Institute for Biochemistry and Biology, Department of Animal Physiology, Potsdam University, Karl-Liebknecht-Str. 24-25, Haus 26, 14476 Potsdam, Germany.Institute of Molecular Biology, Hannover Medical School, Carl-Neuberg Str. 1, D-30625 Hannover, Germany.
Wang Min
Department of Pathology and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06510, USA.
Douglas A. Marchuk
Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.
Issam A. Awad
Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA.
Mark L. Kahn
Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.
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