Research ArticleCEREBRAL CAVERNOUS MALFORMATION

Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation

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Science Translational Medicine  27 Nov 2019:
Vol. 11, Issue 520, eaaw3521
DOI: 10.1126/scitranslmed.aaw3521

Article Information

vol. 11 no. 520

PubMed: 
Print ISSN: 
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History: 
  • Received for publication December 14, 2018
  • Resubmitted July 17, 2019
  • Accepted for publication October 9, 2019
  • .

Author Information

  1. Alan T. Tang1,
  2. Katie R. Sullivan1,
  3. Courtney C. Hong1,
  4. Lauren M. Goddard1,
  5. Aparna Mahadevan1,
  6. Aileen Ren1,
  7. Heidy Pardo2,
  8. Amy Peiper2,
  9. Erin Griffin2,
  10. Ceylan Tanes3,
  11. Lisa M. Mattei3,
  12. Jisheng Yang1,
  13. Li Li1,
  14. Patricia Mericko-Ishizuka1,
  15. Le Shen4,
  16. Nicholas Hobson4,
  17. Romuald Girard4,
  18. Rhonda Lightle4,
  19. Thomas Moore4,
  20. Robert Shenkar4,
  21. Sean P. Polster4,
  22. Claudia J. Roedel5,
  23. Ning Li6,
  24. Qin Zhu7,
  25. Kevin J. Whitehead8,
  26. Xiangjian Zheng9,10,
  27. Amy Akers11,
  28. Leslie Morrison12,
  29. Helen Kim13,
  30. Kyle Bittinger3,
  31. Christopher J. Lengner6,14,15,
  32. Markus Schwaninger16,
  33. Anna Velcich17,
  34. Leonard Augenlicht17,
  35. Salim Abdelilah-Seyfried5,18,
  36. Wang Min19,
  37. Douglas A. Marchuk2,
  38. Issam A. Awad4 and
  39. Mark L. Kahn1,*
  1. 1Department of Medicine and Cardiovascular Institute, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA.
  2. 2Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, USA.
  3. 3Division of Gastroenterology, Hepatology, and Nutrition, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.
  4. 4Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago School of Medicine and Biological Sciences, Chicago, IL 60637, USA.
  5. 5Institute for Biochemistry and Biology, Department of Animal Physiology, Potsdam University, Karl-Liebknecht-Str. 24-25, Haus 26, 14476 Potsdam, Germany.
  6. 6Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  7. 7Graduate Group in Genomics and Computational Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  8. 8Division of Cardiovascular Medicine and the Program in Molecular Medicine, University of Utah, Salt Lake City, UT 84112, USA.
  9. 9Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
  10. 10Centenary Institute, Sydney Medical School, University of Sydney, Sydney, NSW 2050, Australia.
  11. 11Angioma Alliance, Norfolk, VA 23517, USA.
  12. 12Department of Neurology and Pediatrics, University of New Mexico, Albuquerque, NM 87106, USA.
  13. 13Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA.
  14. 14Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  15. 15Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  16. 16Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, 23562 Lübeck, Germany.
  17. 17Department of Cell Biology, Albert Einstein College of Medicine/Albert Einstein Cancer Center, NY 10461, USA.
  18. 18Institute of Molecular Biology, Hannover Medical School, Carl-Neuberg Str. 1, D-30625 Hannover, Germany.
  19. 19Department of Pathology and the Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06510, USA.
  1. *Corresponding author. Email: markkahn{at}pennmedicine.upenn.edu

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