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A meta-analysis of clinical studies conducted during the West Africa Ebola virus disease outbreak confirms the need for randomized control groups

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Science Translational Medicine  27 Nov 2019:
Vol. 11, Issue 520, eaaw1049
DOI: 10.1126/scitranslmed.aaw1049

Article Information

vol. 11 no. 520

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication December 3, 2018
  • Accepted for publication July 4, 2019
  • .

Author Information

  1. Lori E. Dodd1,2,*,
  2. Dean Follmann1,
  3. Michael Proschan1,
  4. Jing Wang3,
  5. Denis Malvy4,5,
  6. Johan van Griensven6,
  7. Iza Ciglenecki7,
  8. Peter W. Horby8,
  9. Rashid Ansumana9,10,
  10. Jia-Fu Jiang11,
  11. Richard T. Davey12,
  12. H. Clifford Lane13 and
  13. Aurelie Gouel-Cheron1,14
  1. 1Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  2. 2School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
  3. 3Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, Frederick, MD, USA.
  4. 4Inserm, UMR 1219, Université de Bordeaux, Bordeaux, France.
  5. 5Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
  6. 6Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
  7. 7Operational Centre Geneva, Médecins Sans Frontières, 1211 Geneva, Switzerland.
  8. 8Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK.
  9. 9Mercy Hospital Research Laboratory, Kulanda Town, Bo, Sierra Leone.
  10. 10School of Community Health Sciences, Njala University, Bo, Sierra Leone.
  11. 11Beijing Institute of Microbiology and Epidemiology, Beijing, China.
  12. 12Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  13. 13Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  14. 14Anesthesiology and Intensive Care Department, Hopital Bichat—Claude Bernard, Assistance Publique—Hopitaux de Paris, Paris, France.
  1. *Corresponding author. Email: doddl{at}mail.nih.gov

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