27 November 2019
Vol 11, Issue 520

About The Cover

Cover image expansion

ONLINE COVER Faulty Vessels: Food for Thought. Shown is a microcomputed tomography scan of cerebral cavernous malformations (CCMs, in red) in a mouse brain. CCM can result from mutations in three different genes and is characterized by abnormal blood vessel formation leading to hemorrhagic stroke and seizures. Tang et al. discovered that mutations in PDCD10 disrupt the gut epithelium in addition to the cerebral vasculature, which contributes to development of a particularly severe form of CCM. Therapeutic strategies targeting PDCD10-mediated signaling in both gut and brain could be effective in treating this severe form of CCM. [CREDIT: TANG ET AL./SCIENCE TRANSLATIONAL MEDICINE]