Research ArticleHIV
Antigenic competition in CD4+ T cell responses in a randomized, multicenter, double-blind clinical HIV vaccine trial
- View ORCID ProfileEsper G. Kallas1,
- View ORCID ProfileNicole A. Grunenberg2,
- Chenchen Yu2,
- View ORCID ProfileBryce Manso2,
- Giuseppe Pantaleo3,
- View ORCID ProfileMartin Casapia4,
- Lindsey R. Baden5,
- View ORCID ProfileJavier Valencia6,
- Magdalena Sobieszczyk7,
- View ORCID ProfileHong Van Tieu8,
- View ORCID ProfileMary Allen9,
- John Hural2,
- View ORCID ProfileBarney S. Graham10,
- View ORCID ProfileJames Kublin2,
- View ORCID ProfilePeter B. Gilbert2,
- View ORCID ProfileLawrence Corey2,
- View ORCID ProfilePaul A. Goepfert11,
- View ORCID ProfileM. Juliana McElrath2,12,13,14,
- View ORCID ProfileR. Paul Johnson15,
- View ORCID ProfileYunda Huang2 and
- View ORCID ProfileNicole Frahm2,12,*
- 1Division of Clinical Immunology and Allergy, University of São Paulo, São Paulo 05508, Brazil.
- 2Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
- 3Division of Immunology and Allergy, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland.
- 4Asociación Civil Selva Amazónica, Iquitos 16002, Peru.
- 5Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
- 6Asociación Civil Impacta Salud Y Educación, Lima 15063, Peru.
- 7Division of Infectious Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA.
- 8Laboratory of Infectious Disease Prevention, New York Blood Center, New York, NY 10065, USA.
- 9Division of AIDS, National Institute for Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
- 10Vaccine Research Center, NIH, Bethesda, MD 20892, USA.
- 11Division of Infectious Disease and Department of Surgery, Division of Gastroenterology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
- 12Department of Global Health, University of Washington, Seattle, WA 98195, USA.
- 13Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.
- 14Department of Medicine, University of Washington, Seattle, WA 98195, USA.
- 15Yerkes National Primate Research Center, School of Medicine, Emory University, Atlanta, GA 30322, USA.
- ↵*Corresponding author. Email: nicole.frahm{at}gatesmri.org
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Science Translational Medicine 20 Nov 2019:
Vol. 11, Issue 519, eaaw1673
DOI: 10.1126/scitranslmed.aaw1673
Vol. 11, Issue 519, eaaw1673
DOI: 10.1126/scitranslmed.aaw1673
Esper G. Kallas
1Division of Clinical Immunology and Allergy, University of São Paulo, São Paulo 05508, Brazil.
Nicole A. Grunenberg
2Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Chenchen Yu
2Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Bryce Manso
2Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Giuseppe Pantaleo
3Division of Immunology and Allergy, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland.
Martin Casapia
4Asociación Civil Selva Amazónica, Iquitos 16002, Peru.
Lindsey R. Baden
5Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Javier Valencia
6Asociación Civil Impacta Salud Y Educación, Lima 15063, Peru.
Magdalena Sobieszczyk
7Division of Infectious Diseases, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10025, USA.
Hong Van Tieu
8Laboratory of Infectious Disease Prevention, New York Blood Center, New York, NY 10065, USA.
Mary Allen
9Division of AIDS, National Institute for Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
John Hural
2Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Barney S. Graham
10Vaccine Research Center, NIH, Bethesda, MD 20892, USA.
James Kublin
2Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Peter B. Gilbert
2Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Lawrence Corey
2Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Paul A. Goepfert
11Division of Infectious Disease and Department of Surgery, Division of Gastroenterology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
M. Juliana McElrath
2Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
12Department of Global Health, University of Washington, Seattle, WA 98195, USA.
13Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.
14Department of Medicine, University of Washington, Seattle, WA 98195, USA.
R. Paul Johnson
15Yerkes National Primate Research Center, School of Medicine, Emory University, Atlanta, GA 30322, USA.
Yunda Huang
2Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Nicole Frahm
2Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
12Department of Global Health, University of Washington, Seattle, WA 98195, USA.
