Research ArticleCancer

Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening

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Science Translational Medicine  20 Nov 2019:
Vol. 11, Issue 519, eaaw0064
DOI: 10.1126/scitranslmed.aaw0064

A systematic attack against brain tumors

Diffuse midline gliomas are aggressive childhood brain tumors that are difficult to access surgically and therefore universally lethal. To search for potential therapeutic options for this devastating cancer, Lin et al. performed high-throughput screening on patient-derived glioma cells, followed by validation in cell cultures and mouse models of the disease. With this approach, the authors identified some potentially useful drug combinations, with the most promising one being that of the epigenetic targeting treatment panobinostat and the proteasome inhibitor marizomib. The authors also investigated the mechanism of the proposed therapeutic combination, linking its effectiveness to the induction of metabolic catastrophe in the tumor cells.

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