20 November 2019
Vol 11, Issue 519

About The Cover

Cover image expansion

ONLINE COVER Putting a Leash on Leishmania. Shown is the infective form of Leishmania braziliensis, a protozoan parasite transmitted by sand flies that causes cutaneous leishmaniasis. Amorim et al. found that expression of cytolytic and immune response genes varied among the skin lesions of patients infected with this parasite depending on whether they responded to standard antimony treatment or not. An expression profile of three to five genes correlated with parasite load in the skin lesions and was able to classify treatment outcome in two cohorts of patients with cutaneous leishmaniasis. These results could help to identify individuals unlikely to respond to conventional treatment and may inform strategies for developing alternate therapies for cutaneous leishmaniasis. [CREDIT: DENNIS KUNKEL MICROSCOPY/SCIENCE SOURCE]