Contents
20 November 2019
Vol 11, Issue 519
Vol 11, Issue 519
Research Articles
- Variable gene expression and parasite load predict treatment outcome in cutaneous leishmaniasis
Variability in immune gene expression between patient lesions predicts treatment outcome in cutaneous leishmaniasis.
- Selective activation of TWIK-related acid-sensitive K+ 3 subunit–containing channels is analgesic in rodent models
Agonists selectively targeting peripheral TWIK-related acid-sensitive K+ 3 subunit–containing channels show potential as non-opioid analgesics.
- Impaired ATM activation in B cells is associated with bone resorption in rheumatoid arthritis
Defective ATM activation skews the B cell repertoire and increases RANKL production, promoting joint erosion in patients with rheumatoid arthritis.
- Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening
High-throughput screens in DMG identify promising treatments, such as the combination of panobinostat and marizomib acting through metabolic collapse.
- Strong TH1-biased CD4 T cell responses are associated with diminished SIV vaccine efficacy
Vaccine-induced IFNγ+ CD4 T cells migrate to and persist in mucosal tissue and negatively associate with protection against SIV.
- Antigenic competition in CD4+ T cell responses in a randomized, multicenter, double-blind clinical HIV vaccine trial
Antigenic competition in CD4+ T cell responses occurs in HIV vaccine recipients.
Editors' Choice
- When T cells lap up lactate
Lactate drives rheumatoid arthritis progression by altering CD4+ T cell metabolism.
- Reversing the effects of early life stress during puberty
Post-institutionalized youth show evidence of pubertal recalibration of stress reactivity.
- Bound to get to the heart of a sticky problem
A cleverly designed biodegradable double-side sticky tape can adhere soft tissues together or to implantable medical devices.
About The Cover
ONLINE COVER Putting a Leash on Leishmania. Shown is the infective form of Leishmania braziliensis, a protozoan parasite transmitted by sand flies that causes cutaneous leishmaniasis. Amorim et al. found that expression of cytolytic and immune response genes varied among the skin lesions of patients infected with this parasite depending on whether they responded to standard antimony treatment or not. An expression profile of three to five genes correlated with parasite load in the skin lesions and was able to classify treatment outcome in two cohorts of patients with cutaneous leishmaniasis. These results could help to identify individuals unlikely to respond to conventional treatment and may inform strategies for developing alternate therapies for cutaneous leishmaniasis. [CREDIT: DENNIS KUNKEL MICROSCOPY/SCIENCE SOURCE]
