Research ArticleSepsis

Prospective clinical testing and experimental validation of the Pediatric Sepsis Biomarker Risk Model

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Science Translational Medicine  13 Nov 2019:
Vol. 11, Issue 518, eaax9000
DOI: 10.1126/scitranslmed.aax9000

Persevering in the face of sepsis

Despite modern therapies, sepsis remains a major clinical problem with a high risk of mortality. Wong et al. validated a tool called PERSEVERE for predicting mortality in the setting of pediatric sepsis and then built on it to compare therapeutic strategies. To enable the use of this approach in experimental models, the authors developed an adapted version of the tool and validated it in a mouse model of sepsis. They then used mice to compare two potential therapeutic strategies, targeting inflammation or focusing on killing bacteria with high-dose antibiotics. The latter approach was much more effective in animals at high risk of death from sepsis.

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