A heat-stable microparticle platform for oral micronutrient delivery

Aaron C. Anselmo; Xian Xu; Simone Buerkli; Yingying Zeng; Wen Tang; Kevin J. McHugh; Adam M. Behrens; Evan Rosenberg; Aranda R. Duan; James L. Sugarman; Jia Zhuang; Joe Collins; Xueguang Lu; Tyler Graf; Stephany Y. Tzeng; Sviatlana Rose; Sarah Acolatse; Thanh D. Nguyen; Xiao Le; Ana Sofia Guerra; Lisa E. Freed; Shelley B. Weinstock; Christopher B. Sears; Boris Nikolic; Lowell Wood; Philip A. Welkhoff; James D. Oxley; Diego Moretti; Michael B. Zimmermann; Robert Langer; Ana Jaklenec

doi:10.1126/scitranslmed.aaw3680

Research ArticleDrug Delivery

A heat-stable microparticle platform for oral micronutrient delivery

View ORCID ProfileAaron C. Anselmo¹,*,†,
View ORCID ProfileXian Xu¹,*,
View ORCID ProfileSimone Buerkli²,*,
View ORCID ProfileYingying Zeng¹,
Wen Tang¹,
View ORCID ProfileKevin J. McHugh¹,‡,
Adam M. Behrens¹,
View ORCID ProfileEvan Rosenberg¹,
Aranda R. Duan¹,
View ORCID ProfileJames L. Sugarman¹,
View ORCID ProfileJia Zhuang¹,
View ORCID ProfileJoe Collins¹,
View ORCID ProfileXueguang Lu¹,
View ORCID ProfileTyler Graf¹,
Stephany Y. Tzeng¹,
Sviatlana Rose¹,
View ORCID ProfileSarah Acolatse¹,
Thanh D. Nguyen¹,§,
Xiao Le¹,
Ana Sofia Guerra³,
View ORCID ProfileLisa E. Freed¹,||,
View ORCID ProfileShelley B. Weinstock⁴,
View ORCID ProfileChristopher B. Sears⁵,
Boris Nikolic⁶,
View ORCID ProfileLowell Wood⁷,
Philip A. Welkhoff⁷,¶,
View ORCID ProfileJames D. Oxley⁸,
View ORCID ProfileDiego Moretti²,#,
Michael B. Zimmermann²,
View ORCID ProfileRobert Langer¹,** and
View ORCID ProfileAna Jaklenec¹,**

¹David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
²Institute of Food Nutrition and Health, ETH Zürich, Zürich 8092, Switzerland.
³Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
⁴Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
⁵Independent Scholar, Belmont, MA 02478, USA.
⁶Biomatics Capital, 1107 1st Avenue, Apartment 1305, Seattle, WA 98101, USA.
⁷Institute for Disease Modeling, Bellevue, WA 98005, USA.
⁸Southwest Research Institute, San Antonio, TX 78238, USA.

↵**Corresponding author. Email: jaklenec{at}mit.edu (A.J.); rlanger{at}mit.edu (R.L.)

↵* These authors contributed equally to this work.
↵† Present address: Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
↵‡ Present address: Department of Bioengineering, Rice University, Houston, TX 77030, USA.
↵§ Present address: Department of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USA.
↵|| Present address: Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
↵¶ Present address: The Bill & Melinda Gates Foundation, Seattle, WA 98109, USA.
↵# Present address: Nutrition Group, Health Department, Swiss Distance University of Applied Sciences, Regensdorf CH-8105, Switzerland.

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Science Translational Medicine 13 Nov 2019:
Vol. 11, Issue 518, eaaw3680
DOI: 10.1126/scitranslmed.aaw3680

Aaron C. Anselmo

1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Xian Xu

1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Simone Buerkli

2Institute of Food Nutrition and Health, ETH Zürich, Zürich 8092, Switzerland.

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Yingying Zeng

1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Wen Tang

1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Kevin J. McHugh

1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Adam M. Behrens

1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Evan Rosenberg

1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Aranda R. Duan

1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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James L. Sugarman

1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Jia Zhuang

1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Joe Collins

1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Xueguang Lu

1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Tyler Graf

1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Stephany Y. Tzeng

1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Sviatlana Rose

1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Sarah Acolatse

1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Thanh D. Nguyen

1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Xiao Le

1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Ana Sofia Guerra

3Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

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Lisa E. Freed

1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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Shelley B. Weinstock

4Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.

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Christopher B. Sears

5Independent Scholar, Belmont, MA 02478, USA.

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Boris Nikolic

6Biomatics Capital, 1107 1st Avenue, Apartment 1305, Seattle, WA 98101, USA.

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Lowell Wood

7Institute for Disease Modeling, Bellevue, WA 98005, USA.

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Philip A. Welkhoff

7Institute for Disease Modeling, Bellevue, WA 98005, USA.

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James D. Oxley

8Southwest Research Institute, San Antonio, TX 78238, USA.

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Diego Moretti

2Institute of Food Nutrition and Health, ETH Zürich, Zürich 8092, Switzerland.

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Michael B. Zimmermann

2Institute of Food Nutrition and Health, ETH Zürich, Zürich 8092, Switzerland.

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Robert Langer

1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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For correspondence: jaklenec@mit.edu rlanger@mit.edu

Ana Jaklenec

1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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For correspondence: jaklenec@mit.edu rlanger@mit.edu

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A heat-stable microparticle platform for oral micronutrient delivery

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