Research ArticleMultiple Sclerosis

Activated leukocyte cell adhesion molecule regulates B lymphocyte migration across central nervous system barriers

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Science Translational Medicine  13 Nov 2019:
Vol. 11, Issue 518, eaaw0475
DOI: 10.1126/scitranslmed.aaw0475

Crossing barriers

Increasing evidence supports a critical role for B lymphocytes in multiple sclerosis (MS). Extravasation of B lymphocytes into the central nervous system promotes disease initiation and progression, and B lymphocyte–targeting therapies have shown potential benefits in experimental models and clinical trials. However, the mechanisms mediating B lymphocyte extravasation are unclear. Now, Michel et al. show that the adhesion molecule ALCAM promoted B lymphocyte extravasation. ALCAM-expressing B cells were increased in serum and brain of patients with MS, and the frequency of ALCAM-expressing B lymphocytes correlated with disease severity in a mouse model of autoimmune encephalomyelitis. Blocking ALCAM reduced disease severity in mice.

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