Research ArticleGUT MICROBIOTA

Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice

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Science Translational Medicine  13 Nov 2019:
Vol. 11, Issue 518, eaau4760
DOI: 10.1126/scitranslmed.aau4760

Article Information

vol. 11 no. 518

Print ISSN: 
Online ISSN: 
  • Received for publication June 14, 2018
  • Resubmitted February 11, 2019
  • Accepted for publication May 20, 2019
  • .

Author Information

  1. Parag Kundu1,2,3,*,
  2. Hae Ung Lee1,
  3. Isabel Garcia-Perez4,
  4. Emmy Xue Yun Tay5,
  5. Hyejin Kim1,
  6. Llanto Elma Faylon2,
  7. Katherine A. Martin1,
  8. Rikky Purbojati2,
  9. Daniela I. Drautz-Moses2,
  10. Sujoy Ghosh6,7,8,
  11. Jeremy K. Nicholson9,
  12. Stephan Schuster2,
  13. Elaine Holmes4,10 and
  14. Sven Pettersson1,2,11,*
  1. 1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.
  2. 2Singapore Centre for Environmental Life Sciences Engineering, Singapore 637551, Singapore.
  3. 3The Center for Microbes, Development and Health, Key Laboratory for Microbiota-Host Interactions, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.
  4. 4Division of Computational and Systems Medicine, Department of Surgery and Cancer, Sir Alexander Fleming Building, Imperial College London, SW72AZ London, UK.
  5. 5Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117557, Singapore.
  6. 6Duke-NUS Medical School, Singapore 169857, Singapore.
  7. 7National Heart Research Institute, Singapore 169609, Singapore.
  8. 8Penningtion Biomedical Research Center, Baton Rouge, LA 70808, USA.
  9. 9Australian National Phenome Center, Murdoch University Perth, Perth, Western Australia, WA6150 Australia.
  10. 10UK Dementia Research Institute at Imperial College London, Burlington Danes Building, Hammersmith Hospital, London, W12 0NN, UK.
  11. 11Department of Neurobiology, Care Sciences and Society, Karolinska Institute, SE 17 177 Stockholm, Sweden.
  1. *Corresponding author. Email: parag.kundu{at}, pkundu{at} (P.K.); sven.pettersson{at} (S.P.)


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