Contents
13 November 2019
Vol 11, Issue 518
Vol 11, Issue 518
Research Articles
- A heat-stable microparticle platform for oral micronutrient delivery
A heat-stable microparticle platform improves oral micronutrient delivery.
- Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice
Transplantation of the gut microbiota of old donor mice into young germ-free mice promotes neurogenesis and prolongevity gene expression signatures.
- Targeting redox heterogeneity to counteract drug tolerance in replicating Mycobacterium tuberculosis
Chloroquine resets the redox physiology of Mycobacterium tuberculosis to potentiate the efficacy of antibiotics in vivo.
- Prospective clinical testing and experimental validation of the Pediatric Sepsis Biomarker Risk Model
Prognostic biomarkers for pediatric septic shock are conserved in a murine model of sepsis and accelerate testing of precision medicine strategies.
- Activated leukocyte cell adhesion molecule regulates B lymphocyte migration across central nervous system barriers
Activated leukocyte cell adhesion molecule mediates B lymphocyte migration across central nervous system barriers.
Editors' Choice
- A whiff of change for dysbiosis treatment
Vaginal microbiome transplantation might be a safe and effective treatment in patients with intractable bacterial vaginosis.
- Recycling resected tonsils for lymphoma research
Tonsillectomy samples can be used to generate in vitro models of high-grade B cell lymphoma.
- A new hope? Yoda1 uses the “force” to sensitize cancer cells to TRAIL-mediated apoptosis
A mechanosensitive ion channel agonist mimics shear stress to enhance the cytotoxic effects of TRAIL on cancer cells.
About The Cover
ONLINE COVER Small Particles, Big Implications. Micronutrient deficiencies contribute to impaired growth and disease and are a leading public health concern in the developing world. This image illustrates encapsulated micronutrient release in the stomach for absorption in the intestine. To improve oral micronutrient delivery, Anselmo et al. formulated heat-stable polymeric microparticles that encapsulated 11 micronutrients, including vitamins A, B2, B12, and iron. Encapsulation stabilized micronutrients against degradation induced by boiling water or cooking and other environmental conditions. The authors performed two clinical trials and experiments in rodents and an in vitro human intestinal tissue model to optimize microparticle formulations, improving iron loading, stability during cooking, and bioavailability while allowing for scale-up. This microparticle platform could help improve oral delivery of micronutrients. [CREDIT: SECOND BAY STUDIOS]
