Research ArticleDRUG TESTING

Reproducing human and cross-species drug toxicities using a Liver-Chip

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Science Translational Medicine  06 Nov 2019:
Vol. 11, Issue 517, eaax5516
DOI: 10.1126/scitranslmed.aax5516

Article Information

vol. 11 no. 517

PubMed: 
Print ISSN: 
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History: 
  • Received for publication April 2, 2019
  • Accepted for publication September 23, 2019
  • .

Author Information

  1. Kyung-Jin Jang1,*,
  2. Monicah A. Otieno2,*,,
  3. Janey Ronxhi1,
  4. Heng-Keang Lim3,
  5. Lorna Ewart4,
  6. Konstantia R. Kodella1,
  7. Debora B. Petropolis1,
  8. Gauri Kulkarni1,
  9. Jonathan E. Rubins1,,
  10. David Conegliano1,
  11. Janna Nawroth1,
  12. Damir Simic2,
  13. Wing Lam3,
  14. Monica Singer2,
  15. Erio Barale2,
  16. Bhanu Singh2,
  17. Manisha Sonee2,
  18. Anthony J. Streeter2,
  19. Carl Manthey5,
  20. Barry Jones4,
  21. Abhishek Srivastava4,
  22. Linda C. Andersson6,
  23. Dominic Williams4,
  24. Hyoungshin Park1,
  25. Riccardo Barrile1,
  26. Josiah Sliz1,
  27. Anna Herland7,§,
  28. Suzzette Haney1,
  29. Katia Karalis1,
  30. Donald E. Ingber7,8,9 and
  31. Geraldine A. Hamilton1,
  1. 1Emulate Inc., 27 Drydock Avenue, Boston, MA 02210, USA.
  2. 2Janssen Pharmaceutical Research and Development, Nonclinical Safety, 1400 Welsh and McKean Road, Spring House, PA 19477, USA.
  3. 3Janssen Pharmaceutical Research and Development, Drug Metabolism and Pharmacokinetics, 1400 Welsh and McKean Road, Spring House, PA 19477, USA.
  4. 4Clinical Pharmacology and Safety Sciences Department, Biopharmaceuticals Science Unit, AstraZeneca, Cambridge, CB4 0WG, UK.
  5. 5Janssen Pharmaceutical Research and Development, IPD Biology, 1400 Welsh and McKean Road, Spring House, PA 19477, USA.
  6. 6Clinical Pharmacology and Safety Sciences Department, Biopharmaceuticals Science Unit, AstraZeneca, Gothenburg SE-431 83, Sweden.
  7. 7Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA.
  8. 8Vascular Biology Program and Department of Surgery, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA.
  9. 9Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02139, USA.
  1. Corresponding author. Email: geraldine.hamilton{at}emulatebio.com (G.A.H.); motieno{at}its.jnj.com (M.A.O.)
  • * These authors contributed equally to this work.

  • Present address: Jnana Therapeutics, Boston, MA 02210, USA.

  • § Present address: Division of Micro and Nanosystems, KTH Royal Institute of Technology, 10044 Stockholm, Sweden and Swedish Medical Nanoscience Center, Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden.

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