Research ArticleAtherosclerosis

Platelet regulation of myeloid suppressor of cytokine signaling 3 accelerates atherosclerosis

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Science Translational Medicine  06 Nov 2019:
Vol. 11, Issue 517, eaax0481
DOI: 10.1126/scitranslmed.aax0481

Platelets and plaques

Platelet activation promotes inflammation, and macrophage-platelet aggregates have been found in cardiovascular disease. Barrett et al. investigated the role of platelets in regulating macrophage polarization in atherosclerosis. Mice with high cholesterol had increased platelet-macrophage aggregates in atherosclerotic plaques, and platelets promoted monocyte recruitment to plaques. Platelets enhanced macrophage expression of myeloid suppressor of cytokine signaling 3 (SOCS3), promoting a proinflammatory phenotype with impaired phagocytosis. Depleting platelets in mice reduced plaque size and macrophage accumulation. SOCS3 was up-regulated, and SOCS1:SOCS3 expression inversely correlated with platelet activity in patients with myocardial infarction and cardiovascular disease. Results elucidate an atherogenic role of platelets via regulation of myeloid inflammation.

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