Research ArticleCancer

Identification of DHODH as a therapeutic target in small cell lung cancer

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Science Translational Medicine  06 Nov 2019:
Vol. 11, Issue 517, eaaw7852
DOI: 10.1126/scitranslmed.aaw7852

Article Information

vol. 11 no. 517

PubMed: 
Print ISSN: 
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History: 
  • Received for publication January 29, 2019
  • Resubmitted July 18, 2019
  • Accepted for publication September 27, 2019
  • .

Author Information

  1. Leanne Li1,*,
  2. Sheng Rong Ng1,2,*,
  3. Caterina I. Colón1,
  4. Benjamin J. Drapkin3,
  5. Peggy P. Hsu1,3,4,
  6. Zhaoqi Li1,2,
  7. Christopher S. Nabel1,3,4,
  8. Caroline A. Lewis5,
  9. Rodrigo Romero1,2,
  10. Kim L. Mercer1,6,
  11. Arjun Bhutkar1,
  12. Sarah Phat3,
  13. David T. Myers3,,
  14. Mandar Deepak Muzumdar1,,
  15. Peter M. K. Westcott1,
  16. Mary Clare Beytagh1,§,
  17. Anna F. Farago3,7,8,
  18. Matthew G. Vander Heiden1,2,4,
  19. Nicholas J. Dyson3,8 and
  20. Tyler Jacks1,2,6,||
  1. 1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  2. 2Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  3. 3Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
  4. 4Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  5. 5Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
  6. 6Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
  7. 7Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  8. 8Harvard Medical School, Boston, MA 02115, USA.
  1. ||Corresponding author. Email: tjacks{at}mit.edu
  • * These authors contributed equally to this work.

  • Present address: Alabama College of Osteopathic Medicine, Dothan, AL 36303, USA.

  • Present address: Department of Genetics and Cancer Biology Institute, Yale University School of Medicine, New Haven, CT 06510, USA.

  • § Present address: University of California, San Francisco, San Francisco, CA 94143, USA.

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