Research ArticleSarcopenia

An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse

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Science Translational Medicine  06 Nov 2019:
Vol. 11, Issue 517, eaaw1131
DOI: 10.1126/scitranslmed.aaw1131

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Counteracting aging muscles

The mechanisms mediating age-related muscle atrophy are not completely understood. Now, Traoré et al. used mouse models to elucidate the mechanisms mediating age-related muscle atrophy. The authors first showed that muscle denervation triggered compensatory mechanisms to counteract excessive muscle loss; after denervation, muscle cells increased the expression of an embryonic isoform of the voltage-gated calcium channel (CaVβ1E) to limit muscle loss. The expression of CaVβ1E was reduced in aged muscles in mice. Moreover, CaVβ1E expression in skeletal muscles correlated with muscle mass in a cohort of aged individuals. The results suggest that targeting CaVβ1E could contribute to prevent muscle atrophy associated with aging and disuse.

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