06 November 2019
Vol 11, Issue 517

About The Cover

Cover image expansion

ONLINE COVER Chipping Away at Drug Toxicity. Tissues- and organs-on-chips are microphysiological systems useful for modeling human disease and testing therapeutic compounds. This artistic rendering of a microfluidic Liver-Chip represents recent work by Jang et al. investigating drug-induced liver toxicity. Using chips containing hepatocytes, Kupffer cells, stellate cells, and sinusoidal endothelial cells from multiple species, the authors identified mechanisms of hepatoxicity of drugs and experimental compounds–some of which showed species-specific effects. The chips recapitulated liver injury induced by oxidative stress and mitochondrial dysfunction caused by a G protein–coupled receptor agonist discontinued in phase 3 trials. Results suggest the Liver-Chip could improve preclinical safety and toxicity testing to select promising candidates for drug development. [CREDIT: BRETT CLAIR AND KYUNG-JIN JANG/EMULATE, INC.]