Focus10TH ANNIVERSARY SERIES

Multiple roles for HIV broadly neutralizing antibodies

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Science Translational Medicine  30 Oct 2019:
Vol. 11, Issue 516, eaaz2686
DOI: 10.1126/scitranslmed.aaz2686

Figures

  • Fig. 1 Strategy for induction of broadly neutralizing antibodies.

    Shown here is the vaccine strategy of sequential prime and boost to induce mature broadly neutralizing antibodies (bnAbs) against HIV. The initial immunogen would engage the precursor naïve B cell of bnAb B cell lineages, and subsequent boosts would select for neutralizing members of the antibody lineage. The classes or types of bnAbs and representative bnAbs are shown in the bottom panel. A successful vaccine will likely need to induce a polyclonal antibody response against multiple bnAb epitopes to cover the full diversity of HIV virus quasi-species to which a vaccinee could be exposed and to avoid transmitted/founder virus escape.

    CREDIT: A. KITTERMAN/SCIENCE TRANSLATIONAL MEDICINE

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