Research ArticleCancer

Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response

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Science Translational Medicine  30 Oct 2019:
Vol. 11, Issue 516, eaax2863
DOI: 10.1126/scitranslmed.aax2863

Article Information

vol. 11 no. 516

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication March 11, 2019
  • Resubmitted June 7, 2019
  • Accepted for publication September 27, 2019
  • .

Author Information

  1. David Sharon1,
  2. Severine Cathelin1,
  3. Sara Mirali1,
  4. Justin M. Di Trani2,
  5. David J. Yanofsky2,3,
  6. Kristine A. Keon2,3,
  7. John L. Rubinstein2,3,
  8. Aaron D. Schimmer1,3,
  9. Troy Ketela1 and
  10. Steven M. Chan1,3,*
  1. 1Princess Margaret Cancer Centre, Toronto, Ontario M5G 1L7, Canada.
  2. 2Molecular Medicine Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.
  3. 3Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
  1. *Corresponding author. Email: steven.chan{at}uhnresearch.ca

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