Research ArticleCancer
Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response
- David Sharon1,
- Severine Cathelin1,
- Sara Mirali1,
- Justin M. Di Trani2,
- David J. Yanofsky2,3,
- Kristine A. Keon2,3,
- John L. Rubinstein2,3,
- Aaron D. Schimmer1,3,
- Troy Ketela1 and
- Steven M. Chan1,3,*
- 1Princess Margaret Cancer Centre, Toronto, Ontario M5G 1L7, Canada.
- 2Molecular Medicine Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada.
- 3Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
- ↵*Corresponding author. Email: steven.chan{at}uhnresearch.ca
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Science Translational Medicine 30 Oct 2019:
Vol. 11, Issue 516, eaax2863
DOI: 10.1126/scitranslmed.aax2863
