Research ArticleFibrosis

Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis

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Science Translational Medicine  30 Oct 2019:
Vol. 11, Issue 516, eaau6296
DOI: 10.1126/scitranslmed.aau6296

Article Information

vol. 11 no. 516

Print ISSN: 
Online ISSN: 
  • Received for publication June 29, 2018
  • Resubmitted March 1, 2019
  • Accepted for publication September 4, 2019
  • .

Author Information

  1. Andrew J. Haak1,
  2. Enis Kostallari2,
  3. Delphine Sicard1,
  4. Giovanni Ligresti1,
  5. Kyoung Moo Choi1,
  6. Nunzia Caporarello1,
  7. Dakota L. Jones1,
  8. Qi Tan1,
  9. Jeffrey Meridew1,
  10. Ana M. Diaz Espinosa1,
  11. Aja Aravamudhan1,
  12. Jessica L. Maiers2,
  13. Rodney D. Britt Jr.1,3,4,
  14. Anja C. Roden5,
  15. Christina M. Pabelick1,3,
  16. Y. S. Prakash1,3,
  17. Seyed Mehdi Nouraie6,
  18. Xiaoyun Li6,
  19. Yingze Zhang6,
  20. Daniel J. Kass6,
  21. David Lagares7,
  22. Andrew M. Tager7,*,
  23. Xaralabos Varelas8,
  24. Vijay H. Shah2 and
  25. Daniel J. Tschumperlin1,
  1. 1Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
  2. 2Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA.
  3. 3Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester MN 55905, USA.
  4. 4Abigail Wexner Research Institute at Nationwide Children's Hospital and Department of Pediatrics, Ohio State University, Columbus, OH 43215, USA.
  5. 5Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester MN 55905, USA.
  6. 6Dorothy P. and Richard P. Simmons Center for Interstitial Lung Disease and Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
  7. 7Division of Pulmonary and Critical Care Medicine, Fibrosis Research Center, and Center for Immunology and Inflammatory Diseases, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
  8. 8Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.
  1. Corresponding author. Email: tschumperlin.daniel{at}


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Article usage: October 2019 to February 2020

Oct 201919611421293
Nov 201947681071764
Dec 20191544233167
Jan 20201259155130
Feb 202092510280

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