Research ArticleRegenerative Medicine

Mesenchymal stem cells promote healing of nonsteroidal anti-inflammatory drug-related peptic ulcer through paracrine actions in pigs

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Science Translational Medicine  30 Oct 2019:
Vol. 11, Issue 516, eaat7455
DOI: 10.1126/scitranslmed.aat7455

Secreting healing factors

One of the main adverse events associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) is the development of gastric ulcers. Proton pump inhibitors are used to alleviate this adverse event; however, they are associated with serious adverse events. Now, Xia et al. developed a porcine model of NSAID-induced gastric ulcers and showed that intragastric administration of adipose tissue–derived mesenchymal stem cells (ADMSCs) rapidly promoted healing and reduced gastric inflammation. The therapeutic effect was mediated by activation of the ErK and Akt pathways in ulcer tissue induced by stem cell–secreted factors. The results suggest that mesenchymal stem cells or their secretome could be effective in treating NSAID-induced gastric ulcers.

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