Research ArticleInfectious Disease

Prunin suppresses viral IRES activity and is a potential candidate for treating enterovirus A71 infection

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Science Translational Medicine  30 Oct 2019:
Vol. 11, Issue 516, eaar5759
DOI: 10.1126/scitranslmed.aar5759

A translational antiviral

Human enterovirus A71 (HEVA71) is a major cause of hand, foot, and mouth disease, which can lead to severe neurological complications including fatality; currently, however, HEVA71 lacks effective treatment options. Gunaseelan et al. screened for compounds that targeted the HEVA71 internal ribosome entry site and thereby impeded viral, but not human, protein synthesis. They found that the flavonoid prunin effectively inhibited HEVA71 protein synthesis in vitro and decreased viral loads and mortality in a mouse model of infection. Prunin may therefore warrant further investigation as a potential treatment option against hand, foot, and mouth disease.

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