Research ArticleInfluenza
Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia
- View ORCID ProfileMart Toots1,
- View ORCID ProfileJeong-Joong Yoon1,
- Robert M. Cox1,
- View ORCID ProfileMichael Hart1,
- View ORCID ProfileZachary M. Sticher2,
- Negar Makhsous3,
- View ORCID ProfileRoland Plesker4,
- View ORCID ProfileAlec H. Barrena1,
- Prabhakar G. Reddy2,
- Deborah G. Mitchell2,
- View ORCID ProfileRyan C. Shean3,
- View ORCID ProfileGregory R. Bluemling2,
- Alexander A. Kolykhalov2,
- View ORCID ProfileAlexander L. Greninger3,
- Michael G. Natchus2,
- George R. Painter2,5 and
- View ORCID ProfileRichard K. Plemper1,*
- 1Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
- 2Emory Institute for Drug Development, Emory University, Atlanta, GA 30322, USA.
- 3Virology Division, Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.
- 4Veterinary Medicine Division, Paul-Ehrlich-Institute, Federal Institute for Vaccines and Biomedicines, 63225 Langen, Germany.
- 5Department of Pharmacology, Emory University, Atlanta, GA 30322, USA.
- ↵*Corresponding author. Email: rplemper{at}gsu.edu
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Science Translational Medicine 23 Oct 2019:
Vol. 11, Issue 515, eaax5866
DOI: 10.1126/scitranslmed.aax5866
Vol. 11, Issue 515, eaax5866
DOI: 10.1126/scitranslmed.aax5866
Mart Toots
1Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
Jeong-Joong Yoon
1Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
Robert M. Cox
1Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
Michael Hart
1Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
Zachary M. Sticher
2Emory Institute for Drug Development, Emory University, Atlanta, GA 30322, USA.
Negar Makhsous
3Virology Division, Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.
Roland Plesker
4Veterinary Medicine Division, Paul-Ehrlich-Institute, Federal Institute for Vaccines and Biomedicines, 63225 Langen, Germany.
Alec H. Barrena
1Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
Prabhakar G. Reddy
2Emory Institute for Drug Development, Emory University, Atlanta, GA 30322, USA.
Deborah G. Mitchell
2Emory Institute for Drug Development, Emory University, Atlanta, GA 30322, USA.
Ryan C. Shean
3Virology Division, Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.
Gregory R. Bluemling
2Emory Institute for Drug Development, Emory University, Atlanta, GA 30322, USA.
Alexander A. Kolykhalov
2Emory Institute for Drug Development, Emory University, Atlanta, GA 30322, USA.
Alexander L. Greninger
3Virology Division, Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.
Michael G. Natchus
2Emory Institute for Drug Development, Emory University, Atlanta, GA 30322, USA.
George R. Painter
2Emory Institute for Drug Development, Emory University, Atlanta, GA 30322, USA.
5Department of Pharmacology, Emory University, Atlanta, GA 30322, USA.
Richard K. Plemper
1Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
