23 October 2019
Vol 11, Issue 515

About The Cover

Cover image expansion

ONLINE COVER Tea Time. The image shows a mouse drinking green tea. Yin et al. used synthetic biology to engineer cells to produce a short variant of human glucagon-like peptide 1 or insulin in response to the green tea metabolite protocatechuic acid (PCA). Diabetic mice and nonhuman primates implanted intraperitoneally with encapsulated engineered cells demonstrated tight control of blood glucose when treated with PCA or after ingesting green tea. This study demonstrates the versatility of synthetic biology for developing engineered cell therapies for diabetes. [CREDIT: YE LABORATORY/EAST CHINA NORMAL UNIVERSITY]