Mutant neuropeptide S receptor reduces sleep duration with preserved memory consolidation

Lijuan Xing; Guangsen Shi; Yulia Mostovoy; Nicholas W. Gentry; Zenghua Fan; Thomas B. McMahon; Pui-Yan Kwok; Christopher R. Jones; Louis J. Ptáček; Ying-Hui Fu

doi:10.1126/scitranslmed.aax2014

Research ArticleSleep

Mutant neuropeptide S receptor reduces sleep duration with preserved memory consolidation

View ORCID ProfileLijuan Xing¹,*,
View ORCID ProfileGuangsen Shi¹,*,
View ORCID ProfileYulia Mostovoy²,
Nicholas W. Gentry¹,
View ORCID ProfileZenghua Fan¹,
View ORCID ProfileThomas B. McMahon¹,
View ORCID ProfilePui-Yan Kwok²,³,⁴,
Christopher R. Jones⁵,
View ORCID ProfileLouis J. Ptáček ¹,⁴,⁶,⁷,† and
View ORCID ProfileYing-Hui Fu ¹,⁴,⁶,⁷,†

¹Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA.
²Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA.
³Department of Dermatology, University of California San Francisco, San Francisco, CA 94143, USA.
⁴Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA.
⁵Department of Neurology, University of Utah, Salt Lake City, UT 84108, USA.
⁶Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94143, USA.
⁷Kavli Institute for Fundamental Neuroscience, University of California San Francisco, San Francisco, CA 94143, USA.

↵†Corresponding author. Email: ljp{at}ucsf.edu (L.J.P.); ying-hui.fu{at}ucsf.edu (Y.-H.F.)

↵* These authors contributed equally to this work.

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Science Translational Medicine 16 Oct 2019:
Vol. 11, Issue 514, eaax2014
DOI: 10.1126/scitranslmed.aax2014

Lijuan Xing

1Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA.

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Guangsen Shi

1Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA.

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Yulia Mostovoy

2Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA.

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Nicholas W. Gentry

1Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA.

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Zenghua Fan

1Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA.

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Thomas B. McMahon

1Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA.

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Pui-Yan Kwok

2Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA.

3Department of Dermatology, University of California San Francisco, San Francisco, CA 94143, USA.

4Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA.

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Christopher R. Jones

5Department of Neurology, University of Utah, Salt Lake City, UT 84108, USA.

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Louis J. Ptáček

1Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA.

4Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA.

6Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94143, USA.

7Kavli Institute for Fundamental Neuroscience, University of California San Francisco, San Francisco, CA 94143, USA.

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For correspondence: ljp@ucsf.edu ying-hui.fu@ucsf.edu

Ying-Hui Fu

1Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA.

4Institute for Human Genetics, University of California San Francisco, San Francisco, CA 94143, USA.

6Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA 94143, USA.

7Kavli Institute for Fundamental Neuroscience, University of California San Francisco, San Francisco, CA 94143, USA.

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For correspondence: ljp@ucsf.edu ying-hui.fu@ucsf.edu

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A human neuropeptide S receptor mutation renders mutant mice to be short sleepers with more resilience to memory deficits caused by sleep deprivation.

Mutant neuropeptide S receptor reduces sleep duration with preserved memory consolidation

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