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Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients

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Science Translational Medicine  09 Oct 2019:
Vol. 11, Issue 513, eaay2574
DOI: 10.1126/scitranslmed.aay2574

Article Information

vol. 11 no. 513

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication June 3, 2019
  • Accepted for publication September 17, 2019
  • .

Author Information

  1. Salo N. Ooft1,2,*,
  2. Fleur Weeber1,2,*,
  3. Krijn K. Dijkstra1,2,,
  4. Chelsea M. McLean1,2,,
  5. Sovann Kaing1,2,
  6. Erik van Werkhoven3,
  7. Luuk Schipper1,2,
  8. Louisa Hoes1,2,
  9. Daniel J. Vis2,4,
  10. Joris van de Haar1,2,4,
  11. Warner Prevoo5,
  12. Petur Snaebjornsson6,
  13. Daphne van der Velden1,2,,
  14. Michelle Klein1,2,
  15. Myriam Chalabi1,
  16. Henk Boot7,
  17. Monique van Leerdam7,
  18. Haiko J. Bloemendal8,
  19. Laurens V. Beerepoot9,
  20. Lodewyk Wessels2,4,10,
  21. Edwin Cuppen2,11,12,
  22. Hans Clevers2,13,14 and
  23. Emile E. Voest1,2,7,§
  1. 1Department of Molecular Oncology and Immunology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
  2. 2Oncode Institute, 3521 AL Utrecht, Netherlands.
  3. 3Department of Biometrics, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
  4. 4Department of Molecular Carcinogenesis, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
  5. 5Department of Radiology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
  6. 6Department of Pathology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
  7. 7Department of Gastrointestinal Oncology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.
  8. 8Department of Internal Medicine/Oncology, Radboud University Medical Center Nijmegen, 6525 GA Nijmegen, Netherlands.
  9. 9Department of Internal Medicine, Elisabeth-TweeSteden Hospital, 5042 AD Tilburg, Netherlands.
  10. 10Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology, 2628 CD Delft, Netherlands.
  11. 11Division Biomedical Genetics, Centre for Molecular Medicine, University Medical Centre Utrecht, 3584 CX Utrecht, Netherlands.
  12. 12Hartwig Medical Foundation, 1098 XH Amsterdam, Netherlands.
  13. 13Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, 3584 CT Utrecht, Netherlands.
  14. 14Princess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, Netherlands.
  1. §Corresponding author. Email: e.voest{at}nki.nl
  • * These authors contributed equally to this work.

  • These authors contributed equally to this work.

  • Present address: Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center AMC, 1105 AZ Amsterdam, Netherlands.

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Dec 2019608186169

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