Research ArticleCancer

An innate-like Vδ1+ γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer

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Science Translational Medicine  09 Oct 2019:
Vol. 11, Issue 513, eaax9364
DOI: 10.1126/scitranslmed.aax9364

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γδ T cells: Guarding and defending tissues

Specific γδ T cell subsets are known to populate tissues such as the skin and gut. To ascertain γδ T cell participation in breast cancer surveillance, Wu et al. isolated cells from grid cultures of human breast tissue. They observed cytolytic innate-like Vδ1+ T cells in healthy human breast tissue as well as tumor tissue. Analysis of a small cohort of women with triple-negative breast cancer revealed that these Vδ1+ T cells were associated with remission and overall survival. These results demonstrate that human tissue-resident γδ T cells may affect breast cancer progression; these cells could be key to existing or future immunotherapy interventions.

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