Research ArticleCardiology

Control of cytokinesis by β-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment

See allHide authors and affiliations

Science Translational Medicine  09 Oct 2019:
Vol. 11, Issue 513, eaaw6419
DOI: 10.1126/scitranslmed.aaw6419

Article Information

vol. 11 no. 513

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication January 11, 2019
  • Resubmitted June 10, 2019
  • Accepted for publication August 30, 2019
  • .

Author Information

  1. Honghai Liu1,*,
  2. Cheng-Hai Zhang2,3,*,,
  3. Niyatie Ammanamanchi1,*,
  4. Sangita Suresh2,3,,
  5. Christopher Lewarchik1,
  6. Krithika Rao1,
  7. Gerrida M. Uys2,3,§,
  8. Lu Han1,
  9. Maryline Abrial2,3,||,
  10. Dean Yimlamai4,
  11. Balakrishnan Ganapathy1,,
  12. Christelle Guillermier5,#,
  13. Nathalie Chen1,
  14. Mugdha Khaladkar6,**,
  15. Jennifer Spaethling7,**,
  16. James H. Eberwine7,
  17. Junhyong Kim6,
  18. Stuart Walsh2,3,††,
  19. Sangita Choudhury2,3,‡‡,
  20. Kathryn Little1,
  21. Kimberly Francis1,§§,
  22. Mahesh Sharma8,
  23. Melita Viegas9,
  24. Abha Bais10,
  25. Dennis Kostka10,11,12,
  26. Jun Ding13,
  27. Ziv Bar-Joseph13,
  28. Yijen Wu10,14,
  29. Vijay Yechoor15,
  30. Mousumi Moulik16,
  31. Jennifer Johnson16,17,
  32. Jacqueline Weinberg16,
  33. Miguel Reyes-Múgica18,
  34. Matthew L. Steinhauser5 and
  35. Bernhard Kühn1,19,20,||||
  1. 1Richard King Mellon Foundation Institute for Pediatric Research and Division of Cardiology, UPMC Children’s Hospital of Pittsburgh and Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15224, USA.
  2. 2Department of Cardiology, Boston Children’s Hospital, Boston, MA 02115, USA.
  3. 3Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
  4. 4Department of Pediatric Gastroenterology, Hepatology and Nutrition, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.
  5. 5Division of Genetics and Harvard Medical School, Brigham and Women’s Hospital, Boston, MA 02115, USA.
  6. 6Department of Biology, School of Arts and Sciences, University of Pennsylvania, 301A/B Lynch Laboratory, 433 S University Avenue, Philadelphia, PA 19104, USA.
  7. 7Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  8. 8Division of Cardiothoracic Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  9. 9Pediatric Cardiothoracic Surgery, UPMC Children’s Hospital of Pittsburgh and Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA 15224, USA.
  10. 10Department of Developmental Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15201, USA.
  11. 11Department of Computational & Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
  12. 12Pittsburgh Center for Evolutionary Biology and Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
  13. 13Computational Biology Department and Machine Learning Department, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
  14. 14Rangos Research Center Animal Imaging Core, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.
  15. 15Diabetes and Beta Cell Biology Center, Division of Endocrinology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15238, USA.
  16. 16Division of Cardiology, Department of Pediatrics, UPMC Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.
  17. 17Neonatal-Perinatal Medicine, UPMC Magee-Womens Hospital, Pittsburgh, PA 15213, USA.
  18. 18Division of Pediatric Pathology, UPMC Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.
  19. 19McGowan Institute of Regenerative Medicine, Pittsburgh, PA 15219, USA.
  20. 20Pediatric Institute for Heart Regeneration and Therapeutics, Pittsburgh, PA 15224, USA.
  1. ||||Corresponding author. Email: bernhard.kuhn2{at}chp.edu
  • * These authors contributed equally to this work.

  • Present address: Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

  • Present address: Roche Sequencing Solutions, Madison, WI 53719, USA.

  • § Present address: 3X4 Genetics, Cape Town, South Africa.

  • || Present address: Celgene, Cambridge, MA 02140, USA.

  • Present address: Biogen, Cambridge, MA 02142, USA.

  • # Present address: Carl Zeiss Microscopy, LLC, One Corporation Way 1, Peabody, MA 01960, USA.

  • ** Present address: GlaxoSmithKline, Collegeville, PA 19426, USA.

  • †† Present address: Schülke & Mayr GmbH, 22851 Norderstedt, Germany.

  • ‡‡ Present address: Department of Genetics and Genomics, Boston Children’s Hospital, Boston, MA 02115, USA.

  • §§ Present address: Mid-Atlantic Regional Public Health Training Center, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA.

Altmetric

Article usage

Article usage: October 2019 to November 2019

AbstractFullPdf
Oct 20195473312859
Nov 20192728857