Research ArticleHIV

The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation

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Science Translational Medicine  09 Oct 2019:
Vol. 11, Issue 513, eaaw5589
DOI: 10.1126/scitranslmed.aaw5589

Article Information

vol. 11 no. 513

PubMed: 
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History: 
  • Received for publication January 4, 2019
  • Accepted for publication August 29, 2019
  • .

Author Information

  1. Melissa-Rose Abrahams1,*,
  2. Sarah B. Joseph2,3,*,
  3. Nigel Garrett4,
  4. Lynn Tyers1,
  5. Matthew Moeser3,
  6. Nancie Archin5,
  7. Olivia D. Council2,
  8. David Matten1,
  9. Shuntai Zhou3,
  10. Deelan Doolabh1,
  11. Colin Anthony1,
  12. Nilu Goonetilleke2,5,
  13. Salim Abdool Karim4,6,
  14. David M. Margolis2,5,
  15. Sergei Kosakovsky Pond7,
  16. Carolyn Williamson1,8, and
  17. Ronald Swanstrom3,9,
  1. 1Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.
  2. 2Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  3. 3Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  4. 4Centre for the AIDS Programme of Research in South Africa, University of KwaZulu- Natal, Durban 4013, South Africa.
  5. 5UNC HIV Cure Center and Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  6. 6Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
  7. 7Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA 19122, USA.
  8. 8National Health Laboratory Services of South Africa, University of Cape Town, Cape Town 7925, South Africa.
  9. 9Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  1. Corresponding author. Email: risunc{at}med.unc.edu (R.S.); carolyn.williamson{at}uct.ac.za (C.W.)
  • * These authors contributed equally to this work.

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