Research ArticleMetabolism

Overproduction of inter-α-trypsin inhibitor heavy chain 1 after loss of Gα13 in liver exacerbates systemic insulin resistance in mice

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Science Translational Medicine  09 Oct 2019:
Vol. 11, Issue 513, eaan4735
DOI: 10.1126/scitranslmed.aan4735

Article Information

vol. 11 no. 513

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History: 
  • Received for publication April 18, 2017
  • Resubmitted February 18, 2018
  • Accepted for publication March 22, 2019
  • .

Author Information

  1. Tae Hyun Kim1,
  2. Ja Hyun Koo1,
  3. Mi Jeong Heo1,
  4. Chang Yeob Han1,
  5. Yong-In Kim2,
  6. Shi-Young Park3,
  7. Il Je Cho4,
  8. Chang Ho Lee5,
  9. Cheol Soo Choi3,6,
  10. Jung Weon Lee1,7,
  11. Won Kim8,*,
  12. Je-Yoel Cho2 and
  13. Sang Geon Kim1,*
  1. 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Korea.
  2. 2Department of Biochemistry, BK21 PLUS Program for Creative Veterinary Science Research and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University , Seoul 08826, Korea.
  3. 3Korea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, Gachon University School of Medicine, Incheon 21999, Korea.
  4. 4College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do 38610, Korea.
  5. 5Department of Pharmacology, Institute of Biomedical Science, College of Medicine, Hanyang University, Seoul, Korea.
  6. 6Endocrinology, Internal Medicine, Gachon University Gil Medical Center, Incheon 21565, Korea.
  7. 7Interdisciplinary Program in Genetic Engineering, Seoul National University, Seoul 08826, Korea.
  8. 8Division of Gastroenterology and Hepatology, Department of Internal Medicine, College of Medicine, Seoul National University, Seoul Metropolitan Government Boramae Medical Center, Seoul, Korea.
  1. *Corresponding author. Email: sgk{at}snu.ac.kr (S.G.K.); drwon1{at}snu.ac.kr (W.K.)

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