Contents
09 October 2019
Vol 11, Issue 513
Vol 11, Issue 513
Research Articles
- The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation
Outgrowth virus phylogeny suggests that most of the long-lived, replication-competent HIV-1 reservoir is formed near the time of therapy initiation.
- Phototherapy and extracorporeal membrane oxygenation facilitate removal of carbon monoxide in rats
Extracorporeal blood phototherapy increases carbon monoxide elimination in rats and improves survival in animals with associated lung injury.
- Control of cytokinesis by β-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment
Control of cytokinesis by β-adrenergic receptors indicates an approach for regulating the established number of cardiomyocytes.
- An innate-like Vδ1+ γδ T cell compartment in the human breast is associated with remission in triple-negative breast cancer
An innate-like γδ T cell compartment in healthy human breast is described and shown to correlate with remission in triple-negative breast cancer.
- Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients
Tumor organoids from individual patients with metastatic colorectal cancer can help predict response to irinotecan with or without 5-fluorouracil.
- Overproduction of inter-α-trypsin inhibitor heavy chain 1 after loss of Gα13 in liver exacerbates systemic insulin resistance in mice
Loss of Gα13 boosts production of liver ITIH1, resulting in systemic insulin resistance in mice that is reversed by ITIH1 neutralization by antibody.
Editors' Choice
- Unplugging brain tumor cells
Electrical coupling of brain tumor cells to neurons drives tumor growth.
- Later is better: Corticosteroids selectively suppress early memory T cells
Systemic corticosteroid therapy selectively affects low-affinity memory CD8+ T cells and may alter the efficacy of immune checkpoint blockade.
- Interfering in Charcot-Marie-Tooth disease 2D
Patient-tailored RNA interference prevents the onset of Charcot-Marie-Tooth 2D disease.
About The Cover
ONLINE COVER Rooting Out the Reservoir. To cure HIV infection, the latent viral reservoir that persists in CD4+ T cells during treatment needs to be eradicated. Abrahams et al. examined viral evolution over time in nine women infected with HIV to understand when the latent reservoir is formed. This phylogenetic tree shows how viruses at different timepoints from a single participant are related; the pink sequences represent the HIV reservoir and are most closely related to viruses identified around the time of treatment initiation. The authors discovered that the latent reservoir is often seeded around the time therapy is given. This evidence could inform future cure efforts aimed at limiting or ablating the HIV reservoir. [CREDIT: ABRAHAMS ET AL./SCIENCE TRANSLATIONAL MEDICINE]
