09 October 2019
Vol 11, Issue 513

About The Cover

Cover image expansion

ONLINE COVER Rooting Out the Reservoir. To cure HIV infection, the latent viral reservoir that persists in CD4+ T cells during treatment needs to be eradicated. Abrahams et al. examined viral evolution over time in nine women infected with HIV to understand when the latent reservoir is formed. This phylogenetic tree shows how viruses at different timepoints from a single participant are related; the pink sequences represent the HIV reservoir and are most closely related to viruses identified around the time of treatment initiation. The authors discovered that the latent reservoir is often seeded around the time therapy is given. This evidence could inform future cure efforts aimed at limiting or ablating the HIV reservoir. [CREDIT: ABRAHAMS ET AL./SCIENCE TRANSLATIONAL MEDICINE]