Research ArticleKidney Disease
Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel
- View ORCID ProfileKaice A. LaFavers1,
- View ORCID ProfileEtienne Macedo2,
- View ORCID ProfilePranav S. Garimella2,
- View ORCID ProfileCamila Lima3,
- Shehnaz Khan1,
- View ORCID ProfileJered Myslinski1,
- View ORCID ProfileJeanette McClintick4,
- View ORCID ProfileFrank A. Witzmann5,
- View ORCID ProfileSeth Winfree1,5,
- View ORCID ProfileCarrie L. Phillips6,
- View ORCID ProfileTakashi Hato1,
- View ORCID ProfilePierre C. Dagher1,5,7,
- Xue-Ru Wu8,
- View ORCID ProfileTarek M. El-Achkar1,5,7,9,*,† and
- View ORCID ProfileRadmila Micanovic1
- 1Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
- 2Division of Nephrology-Hypertension, Department of Medicine, University of California San Diego, San Diego, CA 92093, USA.
- 3Division of Nephrology, Department of Medicine, University of Sao Paulo, Sao Paulo 05403, Brazil.
- 4Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
- 5Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
- 6Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
- 7Richard L. Roudebush VA Medical Center, Indianapolis, IN 46202, USA.
- 8Departments of Urology and Pathology, New York University School of Medicine and Veterans Affairs, New York Harbor Healthcare System, Manhattan Campus, New York, NY 10010, USA.
- 9Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
- ↵†Corresponding author. Email: telachka{at}iu.edu
↵* Present address: Division of Nephrology, Indiana University School of Medicine, 950 W. Walnut, R2 202, Indianapolis, IN 46202, USA.
See allHide authors and affiliations
Science Translational Medicine 02 Oct 2019:
Vol. 11, Issue 512, eaaw3639
DOI: 10.1126/scitranslmed.aaw3639
Vol. 11, Issue 512, eaaw3639
DOI: 10.1126/scitranslmed.aaw3639
Kaice A. LaFavers
1Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Etienne Macedo
2Division of Nephrology-Hypertension, Department of Medicine, University of California San Diego, San Diego, CA 92093, USA.
Pranav S. Garimella
2Division of Nephrology-Hypertension, Department of Medicine, University of California San Diego, San Diego, CA 92093, USA.
Camila Lima
3Division of Nephrology, Department of Medicine, University of Sao Paulo, Sao Paulo 05403, Brazil.
Shehnaz Khan
1Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Jered Myslinski
1Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Jeanette McClintick
4Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Frank A. Witzmann
5Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Seth Winfree
1Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
5Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Carrie L. Phillips
6Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Takashi Hato
1Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Pierre C. Dagher
1Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
5Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
7Richard L. Roudebush VA Medical Center, Indianapolis, IN 46202, USA.
Xue-Ru Wu
8Departments of Urology and Pathology, New York University School of Medicine and Veterans Affairs, New York Harbor Healthcare System, Manhattan Campus, New York, NY 10010, USA.
Tarek M. El-Achkar
1Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
5Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
7Richard L. Roudebush VA Medical Center, Indianapolis, IN 46202, USA.
9Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Radmila Micanovic
1Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
