Research ArticleKidney Disease

Circulating uromodulin inhibits systemic oxidative stress by inactivating the TRPM2 channel

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Science Translational Medicine  02 Oct 2019:
Vol. 11, Issue 512, eaaw3639
DOI: 10.1126/scitranslmed.aaw3639

Article Information

vol. 11 no. 512

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication December 12, 2018
  • Resubmitted April 26, 2019
  • Accepted for publication August 22, 2019
  • .

Author Information

  1. Kaice A. LaFavers1,
  2. Etienne Macedo2,
  3. Pranav S. Garimella2,
  4. Camila Lima3,
  5. Shehnaz Khan1,
  6. Jered Myslinski1,
  7. Jeanette McClintick4,
  8. Frank A. Witzmann5,
  9. Seth Winfree1,5,
  10. Carrie L. Phillips6,
  11. Takashi Hato1,
  12. Pierre C. Dagher1,5,7,
  13. Xue-Ru Wu8,
  14. Tarek M. El-Achkar1,5,7,9,*, and
  15. Radmila Micanovic1
  1. 1Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  2. 2Division of Nephrology-Hypertension, Department of Medicine, University of California San Diego, San Diego, CA 92093, USA.
  3. 3Division of Nephrology, Department of Medicine, University of Sao Paulo, Sao Paulo 05403, Brazil.
  4. 4Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  5. 5Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  6. 6Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  7. 7Richard L. Roudebush VA Medical Center, Indianapolis, IN 46202, USA.
  8. 8Departments of Urology and Pathology, New York University School of Medicine and Veterans Affairs, New York Harbor Healthcare System, Manhattan Campus, New York, NY 10010, USA.
  9. 9Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
  1. Corresponding author. Email: telachka{at}iu.edu
  • * Present address: Division of Nephrology, Indiana University School of Medicine, 950 W. Walnut, R2 202, Indianapolis, IN 46202, USA.

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