Research ArticleCancer

CAR T cells targeting BAFF-R can overcome CD19 antigen loss in B cell malignancies

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Science Translational Medicine  25 Sep 2019:
Vol. 11, Issue 511, eaaw9414
DOI: 10.1126/scitranslmed.aaw9414

Article Information

vol. 11 no. 511

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 7, 2019
  • Resubmitted April 3, 2019
  • Accepted for publication July 31, 2019
  • .

Author Information

  1. Hong Qin1,*,
  2. Zhenyuan Dong1,*,
  3. Xiuli Wang2,
  4. Wesley A. Cheng1,
  5. Feng Wen1,3,
  6. Weili Xue1,4,
  7. Han Sun1,
  8. Miriam Walter2,
  9. Guowei Wei1,
  10. D. Lynne Smith1,
  11. Xiuhua Sun5,
  12. Fan Fei6,
  13. Jianming Xie6,
  14. Theano I. Panagopoulou7,
  15. Chun-Wei Chen7,
  16. Joo Y. Song8,
  17. Ibrahim Aldoss9,
  18. Clarisse Kayembe10,
  19. Luisa Sarno10,
  20. Markus Müschen7,
  21. Giorgio G. Inghirami10,
  22. Stephen J. Forman2 and
  23. Larry W. Kwak1,
  1. 1Toni Stephenson Lymphoma Center, Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
  2. 2Center for CAR T Cell Therapy, Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
  3. 3Department of Medical Oncology Cancer Center, West China Hospital, Sichuan University, Sichuan 910041, China.
  4. 4The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450001, China.
  5. 5The Second Affiliated Hospital of Dalian Medical University, Dalian 116044, China.
  6. 6Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, CA 90007, USA.
  7. 7Department of Systems Biology, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
  8. 8Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA.
  9. 9Gehr Family Center for Leukemia Research, Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.
  10. 10Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
  1. Corresponding author. Email: lkwak{at}coh.org
  • * These authors contributed equally to this work.

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Sep 201925867061484
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Nov 20193427992