25 September 2019
Vol 11, Issue 511

About The Cover

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ONLINE COVER Attacking Fibroblast Activation. Antifibrotic treatments for idiopathic pulmonary fibrosis (IPF) are only partially effective and cause severe adverse effects. In search of new therapeutic targets, Ng et al. examined lung tissue from patients with IPF and found upregulation of interleukin-11 (IL-11) in invasive fibroblasts. This image of a mouse lung tissue section shows collagen expression (green) after IL-11 administration. Exogenous IL-11 triggered fibroblast invasion and lung fibrosis in mice. Giving mice an anti-IL-11 neutralizing antibody reduced lung inflammation and reversed bleomycin-induced fibrosis, suggesting that IL-11 might be an effective target for treating IPF. [CREDIT: NG ET AL./SCIENCE TRANSLATIONAL MEDICINE]