Research ArticleKidney Disease
Yin Yang 1 protein ameliorates diabetic nephropathy pathology through transcriptional repression of TGFβ1
- View ORCID ProfilePan Gao1,*,†,
- View ORCID ProfileLiliang Li2,*,
- View ORCID ProfileLiu Yang1,‡,
- View ORCID ProfileDingkun Gui3,
- View ORCID ProfileJiarong Zhang4,
- View ORCID ProfileJunfeng Han1,
- View ORCID ProfileJiajia Wang5,
- View ORCID ProfileNiansong Wang5,
- View ORCID ProfileJunxi Lu1,
- View ORCID ProfileSuzhen Chen1,
- View ORCID ProfileLiping Hou1,
- View ORCID ProfileHonglin Sun1,
- View ORCID ProfileLiping Xie1,
- View ORCID ProfileJian Zhou1,
- View ORCID ProfileChao Peng6,
- View ORCID ProfileYan Lu7,
- View ORCID ProfileXuemei Peng8,
- View ORCID ProfileCunchuan Wang8,
- View ORCID ProfileJi Miao9,
- View ORCID ProfileUmut Ozcan9,
- View ORCID ProfileYu Huang10,
- View ORCID ProfileWeiping Jia1,‡ and
- View ORCID ProfileJunli Liu1,‡
- 1Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.
- 2Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
- 3Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200032, China.
- 4State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
- 5Department of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou 213001, China.
- 6National Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai 201210, China.
- 7Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200025, China.
- 8Department of Metabolic and Bariatric Surgery, First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
- 9Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
- 10School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong 999077, China.
- ↵‡Corresponding author. Email: yangliu.2009.0817{at}gmail.com (L.Y.); wpjia{at}sjtu.edu.cn (W.J.); liujunli{at}sjtu.edu.cn (J.L.)
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Science Translational Medicine 18 Sep 2019:
Vol. 11, Issue 510, eaaw2050
DOI: 10.1126/scitranslmed.aaw2050
Vol. 11, Issue 510, eaaw2050
DOI: 10.1126/scitranslmed.aaw2050
Pan Gao
1Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.
Liliang Li
2Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Liu Yang
1Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.
Dingkun Gui
3Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200032, China.
Jiarong Zhang
4State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Junfeng Han
1Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.
Jiajia Wang
5Department of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou 213001, China.
Niansong Wang
5Department of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou 213001, China.
Junxi Lu
1Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.
Suzhen Chen
1Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.
Liping Hou
1Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.
Honglin Sun
1Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.
Liping Xie
1Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.
Jian Zhou
1Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.
Chao Peng
6National Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai 201210, China.
Yan Lu
7Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200025, China.
Xuemei Peng
8Department of Metabolic and Bariatric Surgery, First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Cunchuan Wang
8Department of Metabolic and Bariatric Surgery, First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Ji Miao
9Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Umut Ozcan
9Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
Yu Huang
10School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong 999077, China.
Weiping Jia
1Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.
Junli Liu
1Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.
