Research ArticleKidney Disease

Yin Yang 1 protein ameliorates diabetic nephropathy pathology through transcriptional repression of TGFβ1

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Science Translational Medicine  18 Sep 2019:
Vol. 11, Issue 510, eaaw2050
DOI: 10.1126/scitranslmed.aaw2050

Article Information

vol. 11 no. 510

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History: 
  • Received for publication November 28, 2018
  • Accepted for publication August 29, 2019
  • .

Author Information

  1. Pan Gao1,*,,
  2. Liliang Li2,*,
  3. Liu Yang1,,
  4. Dingkun Gui3,
  5. Jiarong Zhang4,
  6. Junfeng Han1,
  7. Jiajia Wang5,
  8. Niansong Wang5,
  9. Junxi Lu1,
  10. Suzhen Chen1,
  11. Liping Hou1,
  12. Honglin Sun1,
  13. Liping Xie1,
  14. Jian Zhou1,
  15. Chao Peng6,
  16. Yan Lu7,
  17. Xuemei Peng8,
  18. Cunchuan Wang8,
  19. Ji Miao9,
  20. Umut Ozcan9,
  21. Yu Huang10,
  22. Weiping Jia1, and
  23. Junli Liu1,
  1. 1Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200032, China.
  2. 2Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
  3. 3Department of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200032, China.
  4. 4State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
  5. 5Department of Endocrinology, Third Affiliated Hospital of Soochow University, Changzhou 213001, China.
  6. 6National Facility for Protein Science in Shanghai, Zhangjiang Lab, Shanghai 201210, China.
  7. 7Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200025, China.
  8. 8Department of Metabolic and Bariatric Surgery, First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
  9. 9Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA.
  10. 10School of Biomedical Sciences, Chinese University of Hong Kong, Hong Kong 999077, China.
  1. Corresponding author. Email: yangliu.2009.0817{at}gmail.com (L.Y.); wpjia{at}sjtu.edu.cn (W.J.); liujunli{at}sjtu.edu.cn (J.L.)
  • * These authors contributed equally to this work.

  • Present address: Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

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