Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases

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  Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases

  By Ioannis Akoumianakis, Fabio Sanna, Marios Margaritis, Ileana Badi, Nadia Akawi, Laura Herdman, Patricia Coutinho, Harry Fagan, Alexios S. Antonopoulos, Evangelos K. Oikonomou, Sheena Thomas, Amy P. Chiu, Surawee Chuaiphichai, Christos P. Kotanidis, Constantinos Christodoulides, Mario Petrou, George Krasopoulos, Rana Sayeed, Lei Lv, Ashley Hale, Meisam Naeimi Kararoudi, Eileen McNeill, Gillian Douglas, Sarah George, Dimitris Tousoulis, Keith M. Channon, Charalambos Antoniades

  Science Translational Medicine18 Sep 2019

  Adipose-secreted WNT5A triggers vascular disease in obesity, activating vascular smooth muscle cell migration by an NADPH oxidase–dependent mechanism.

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  Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases

  By Ioannis Akoumianakis, Fabio Sanna, Marios Margaritis, Ileana Badi, Nadia Akawi, Laura Herdman, Patricia Coutinho, Harry Fagan, Alexios S. Antonopoulos, Evangelos K. Oikonomou, Sheena Thomas, Amy P. Chiu, Surawee Chuaiphichai, Christos P. Kotanidis, Constantinos Christodoulides, Mario Petrou, George Krasopoulos, Rana Sayeed, Lei Lv, Ashley Hale, Meisam Naeimi Kararoudi, Eileen McNeill, Gillian Douglas, Sarah George, Dimitris Tousoulis, Keith M. Channon, Charalambos Antoniades

  Science Translational Medicine18 Sep 2019

  Adipose-secreted WNT5A triggers vascular disease in obesity, activating vascular smooth muscle cell migration by an NADPH oxidase–dependent mechanism.

  • Supplementary Materials

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