Research ArticleCARDIOMETABOLIC DISEASE
Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases
- View ORCID ProfileIoannis Akoumianakis1,*,
- View ORCID ProfileFabio Sanna1,*,
- View ORCID ProfileMarios Margaritis1,
- View ORCID ProfileIleana Badi1,
- View ORCID ProfileNadia Akawi1,
- View ORCID ProfileLaura Herdman1,
- View ORCID ProfilePatricia Coutinho1,
- Harry Fagan1,
- View ORCID ProfileAlexios S. Antonopoulos1,
- View ORCID ProfileEvangelos K. Oikonomou1,
- View ORCID ProfileSheena Thomas1,
- Amy P. Chiu1,
- Surawee Chuaiphichai1,
- View ORCID ProfileChristos P. Kotanidis1,
- Constantinos Christodoulides2,
- View ORCID ProfileMario Petrou3,
- View ORCID ProfileGeorge Krasopoulos3,
- View ORCID ProfileRana Sayeed3,
- Lei Lv1,
- Ashley Hale1,
- Meisam Naeimi Kararoudi1,
- Eileen McNeill1,
- Gillian Douglas1,
- View ORCID ProfileSarah George4,
- View ORCID ProfileDimitris Tousoulis5,
- View ORCID ProfileKeith M. Channon1 and
- View ORCID ProfileCharalambos Antoniades1,†
- 1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
- 2Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK.
- 3Department of Cardiothoracic Surgery, Oxford University Hospitals NHS Trust, Oxford, OX3 9DU, UK.
- 4Bristol Medical School, University of Bristol, Research Floor Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, UK.
- 5Cardiology Department, Athens University Medical School, Athens 115 27, Greece.
- ↵†Corresponding author. Email: antoniad{at}well.ox.ac.uk
↵* These authors contributed equally to this work.
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Science Translational Medicine 18 Sep 2019:
Vol. 11, Issue 510, eaav5055
DOI: 10.1126/scitranslmed.aav5055
Vol. 11, Issue 510, eaav5055
DOI: 10.1126/scitranslmed.aav5055
Ioannis Akoumianakis
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Fabio Sanna
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Marios Margaritis
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Ileana Badi
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Nadia Akawi
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Laura Herdman
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Patricia Coutinho
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Harry Fagan
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Alexios S. Antonopoulos
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Evangelos K. Oikonomou
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Sheena Thomas
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Amy P. Chiu
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Surawee Chuaiphichai
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Christos P. Kotanidis
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Constantinos Christodoulides
2Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, OX3 7LE, UK.
Mario Petrou
3Department of Cardiothoracic Surgery, Oxford University Hospitals NHS Trust, Oxford, OX3 9DU, UK.
George Krasopoulos
3Department of Cardiothoracic Surgery, Oxford University Hospitals NHS Trust, Oxford, OX3 9DU, UK.
Rana Sayeed
3Department of Cardiothoracic Surgery, Oxford University Hospitals NHS Trust, Oxford, OX3 9DU, UK.
Lei Lv
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Ashley Hale
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Meisam Naeimi Kararoudi
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Eileen McNeill
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Gillian Douglas
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Sarah George
4Bristol Medical School, University of Bristol, Research Floor Level 7, Bristol Royal Infirmary, Bristol BS2 8HW, UK.
Dimitris Tousoulis
5Cardiology Department, Athens University Medical School, Athens 115 27, Greece.
Keith M. Channon
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
Charalambos Antoniades
1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9DU, UK.
