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Adiposity and artery disease
Obesity is a risk factor for cardiovascular disease. Akoumianakis and colleagues studied the link between obesity and atherosclerosis, finding that adipokines that regulate noncanonical Wnt signaling were dysregulated. Patients who were obese and those with coronary artery disease had high amounts of plasma WNT5A, which was associated with progression of calcified plaques. Mechanistically, WNT5A secreted by perivascular adipose tissue induced oxidative stress in blood vessel walls and migration of smooth muscle cells. This study helps shed light on the interaction between adipose tissue and blood vessels and identifies a potential therapeutic target for cardiometabolic disease.
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