Research ArticleCARDIOMETABOLIC DISEASE

Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases

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Science Translational Medicine  18 Sep 2019:
Vol. 11, Issue 510, eaav5055
DOI: 10.1126/scitranslmed.aav5055

Adiposity and artery disease

Obesity is a risk factor for cardiovascular disease. Akoumianakis and colleagues studied the link between obesity and atherosclerosis, finding that adipokines that regulate noncanonical Wnt signaling were dysregulated. Patients who were obese and those with coronary artery disease had high amounts of plasma WNT5A, which was associated with progression of calcified plaques. Mechanistically, WNT5A secreted by perivascular adipose tissue induced oxidative stress in blood vessel walls and migration of smooth muscle cells. This study helps shed light on the interaction between adipose tissue and blood vessels and identifies a potential therapeutic target for cardiometabolic disease.

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