Research ArticleMalaria

Antimalarial pantothenamide metabolites target acetyl–coenzyme A biosynthesis in Plasmodium falciparum

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Science Translational Medicine  18 Sep 2019:
Vol. 11, Issue 510, eaas9917
DOI: 10.1126/scitranslmed.aas9917

Article Information

vol. 11 no. 510

PubMed: 
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History: 
  • Received for publication January 12, 2018
  • Resubmitted September 7, 2018
  • Accepted for publication March 28, 2019
  • .

Author Information

  1. Joost Schalkwijk1,*,,
  2. Erik L. Allman2,*,
  3. Patrick A. M. Jansen1,*,
  4. Laura E. de Vries3,*,
  5. Julie M. J. Verhoef3,
  6. Suzanne Jackowski4,
  7. Peter N. M. Botman5,
  8. Christien A. Beuckens-Schortinghuis5,
  9. Karin M. J. Koolen6,
  10. Judith M. Bolscher6,
  11. Martijn W. Vos6,
  12. Karen Miller4,
  13. Stacy A. Reeves4,
  14. Helmi Pett3,
  15. Graham Trevitt7,
  16. Sergio Wittlin8,9,
  17. Christian Scheurer8,9,
  18. Sibylle Sax8,9,
  19. Christoph Fischli8,9,
  20. Iñigo Angulo-Barturen10,
  21. Mariá Belén Jiménez-Diaz10,
  22. Gabrielle Josling2,
  23. Taco W. A. Kooij3,
  24. Roger Bonnert11,
  25. Brice Campo11,
  26. Richard H. Blaauw5,
  27. Floris P. J. T. Rutjes12,
  28. Robert W. Sauerwein3,6,
  29. Manuel Llinás2,13,
  30. Pedro H. H. Hermkens14, and
  31. Koen J. Dechering6,,
  1. 1Department of Dermatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
  2. 2Department of Biochemistry and Molecular Biology and Huck Center for Malaria Research, The Pennsylvania State University, University Park, PA 16802 USA.
  3. 3Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
  4. 4St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  5. 5Chiralix, Nijmegen, Netherlands.
  6. 6TropIQ Health Sciences, Nijmegen, Netherlands.
  7. 7XenoGesis Ltd., Nottingham, UK.
  8. 8Swiss Tropical and Public Health Institute, Basel, Switzerland.
  9. 9University of Basel, Basel, Switzerland.
  10. 10The Art of Discovery, Derio, Spain.
  11. 11Medicines for Malaria Venture, Geneva, Switzerland.
  12. 12Radboud University, Nijmegen, Netherlands.
  13. 13Department of Chemistry, The Pennsylvania State University, University Park, PA 16802 USA.
  14. 14Hermkens Pharma Consultancy, Oss, Netherlands.
  1. Corresponding author. Email: joost.schalkwijk{at}radboudumc.nl (J.S.); k.dechering{at}tropiq.nl (K.J.D.)
  • * These authors contributed equally to this work.

  • These authors contributed equally to this work.

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