Research ArticleCancer

Machine learning analysis of DNA methylation profiles distinguishes primary lung squamous cell carcinomas from head and neck metastases

See allHide authors and affiliations

Science Translational Medicine  11 Sep 2019:
Vol. 11, Issue 509, eaaw8513
DOI: 10.1126/scitranslmed.aaw8513

Article Information

vol. 11 no. 509

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 4, 2019
  • Accepted for publication August 22, 2019
  • .

Author Information

  1. Philipp Jurmeister1,2,3,*,
  2. Michael Bockmayr1,4,5,*,
  3. Philipp Seegerer6,
  4. Teresa Bockmayr1,
  5. Denise Treue1,
  6. Grégoire Montavon6,
  7. Claudia Vollbrecht1,3,7,
  8. Alexander Arnold1,
  9. Daniel Teichmann8,
  10. Keno Bressem9,
  11. Ulrich Schüller4,5,10,
  12. Maximilian von Laffert1,
  13. Klaus-Robert Müller6,11,12,
  14. David Capper3,8, and
  15. Frederick Klauschen1,3,
  1. 1Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 10117 Berlin, Germany.
  2. 2Charité Comprehensive Cancer Center, 10117 Berlin, Germany.
  3. 3German Cancer Consortium (DKTK), Partner Site Berlin, and German Cancer Research Center (DKFZ), 69210 Heidelberg, Germany.
  4. 4Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
  5. 5Research Institute Children's Cancer Center Hamburg, 20251 Hamburg, Germany.
  6. 6Machine-Learning Group, Department of Software Engineering and Theoretical Computer Science, Technical University of Berlin, 10623 Berlin, Germany.
  7. 7German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
  8. 8Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 10117 Berlin, Germany.
  9. 9Department of Radiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, 10117 Berlin, Germany.
  10. 10Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
  11. 11Department of Brain and Cognitive Engineering, Korea University, 136-713 Seoul, South Korea.
  12. 12Max-Planck-Institute for Informatics, 66123 Saarbrücken, Germany.
  1. Corresponding author. Email: frederick.klauschen{at}charite.de (F.K.); david.capper{at}charite.de (D.C.)
  • * These authors contributed equally to this work.

Altmetric

Article usage

Article usage: September 2019 to July 2020

AbstractFullPdf
Sep 201961541605646
Oct 2019648249127
Nov 2019614132101
Dec 201910218157
Jan 202093510952
Feb 20208495446
Mar 20205197340
Apr 20202228743
May 20202464224
Jun 20202065629
Jul 202065157

Stay Connected to Science Translational Medicine