Research ArticleOsteoarthritis

Topographic modeling of early human osteoarthritis in sheep

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Science Translational Medicine  04 Sep 2019:
Vol. 11, Issue 508, eaax6775
DOI: 10.1126/scitranslmed.aax6775

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Deciphering degeneration

Aging and injury are known to contribute to osteoarthritis, a disease characterized by the breakdown of cartilage. Here, Oláh et al. induced meniscal injury in sheep and created detailed maps of disease progression. They found that cartilage and bone breakdown occurred first in the injured region before spreading throughout the joint. Patterns of degeneration observed in the sheep 6 months after injury mirrored pathology observed in human osteoarthritis. This large animal model of osteoarthritis could be useful for furthering our understanding of disease progression and for testing potential therapies.

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