Research ArticleCancer

Overcoming adaptive therapy resistance in AML by targeting immune response pathways

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Science Translational Medicine  04 Sep 2019:
Vol. 11, Issue 508, eaaw8828
DOI: 10.1126/scitranslmed.aaw8828

Article Information

vol. 11 no. 508

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication February 4, 2019
  • Accepted for publication July 24, 2019
  • .

Author Information

  1. Katelyn Melgar1,2,
  2. Morgan M. Walker3,
  3. LaQuita M. Jones4,
  4. Lyndsey C. Bolanos1,
  5. Kathleen Hueneman1,
  6. Mark Wunderlich1,
  7. Jiang-Kang Jiang3,
  8. Kelli M. Wilson3,
  9. Xiaohu Zhang3,
  10. Patrick Sutter3,
  11. Amy Wang3,
  12. Xin Xu3,
  13. Kwangmin Choi1,
  14. Gregory Tawa3,
  15. Donald Lorimer4,
  16. Jan Abendroth4,
  17. Eric O’Brien5,
  18. Scott B. Hoyt3,
  19. Ellin Berman6,
  20. Christopher A. Famulare7,
  21. James C. Mulloy1,
  22. Ross L. Levine6,7,8,
  23. John P. Perentesis5,
  24. Craig J. Thomas3,9,* and
  25. Daniel T. Starczynowski1,10,*
  1. 1Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.
  2. 2Immunology Graduate Program, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
  3. 3Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.
  4. 4UCB Bainbridge, Bainbridge Island, WA 98110, USA.
  5. 5Division of Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.
  6. 6Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  7. 7Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  8. 8Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  9. 9Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20829, USA.
  10. 10Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
  1. *Corresponding author. Email: craigt{at}mail.nih.gov (C.J.T.); daniel.starczynowski{at}cchmc.org (D.T.S.)

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