In vivo detection of cerebral tau pathology in long-term survivors of traumatic brain injury

Nikos Gorgoraptis; Lucia M. Li; Alex Whittington; Karl A. Zimmerman; Linda M. Maclean; Claire McLeod; Ewan Ross; Amanda Heslegrave; Henrik Zetterberg; Jan Passchier; Paul M. Matthews; Roger N. Gunn; Tom M. McMillan; David J. Sharp

doi:10.1126/scitranslmed.aaw1993

Research ArticleTraumatic Brain Injury

In vivo detection of cerebral tau pathology in long-term survivors of traumatic brain injury

View ORCID ProfileNikos Gorgoraptis¹,
Lucia M. Li¹,
View ORCID ProfileAlex Whittington¹,²,
View ORCID ProfileKarl A. Zimmerman¹,
Linda M. Maclean³,
Claire McLeod³,
View ORCID ProfileEwan Ross¹,
View ORCID ProfileAmanda Heslegrave⁴,⁵,
Henrik Zetterberg⁴,⁵,⁶,⁷,
Jan Passchier²,
View ORCID ProfilePaul M. Matthews¹,⁸,
View ORCID ProfileRoger N. Gunn¹,²,
View ORCID ProfileTom M. McMillan³ and
View ORCID ProfileDavid J. Sharp ¹,⁸,⁹,*

¹Department of Brain Sciences, Imperial College London, London W12 0NN, UK.
²Invicro London, London W12 0NN, UK.
³Institute of Health and Wellbeing, University of Glasgow, Glasgow G12 0XH, UK.
⁴UK Dementia Research Institute, University College London, London WC1N 3BG, UK.
⁵Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
⁶Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal 431 80, Sweden.
⁷Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal 413 45, Sweden.
⁸UK Dementia Research Institute, Imperial College London, London W12 0NN, UK.
⁹Royal British Legion Centre for Blast Injury Studies, Imperial College London, London, UK.

↵*Corresponding author. Email: david.sharp{at}imperial.ac.uk

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Science Translational Medicine 04 Sep 2019:
Vol. 11, Issue 508, eaaw1993
DOI: 10.1126/scitranslmed.aaw1993

Nikos Gorgoraptis

1Department of Brain Sciences, Imperial College London, London W12 0NN, UK.

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Lucia M. Li

1Department of Brain Sciences, Imperial College London, London W12 0NN, UK.

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Alex Whittington

1Department of Brain Sciences, Imperial College London, London W12 0NN, UK.

2Invicro London, London W12 0NN, UK.

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Karl A. Zimmerman

1Department of Brain Sciences, Imperial College London, London W12 0NN, UK.

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Linda M. Maclean

3Institute of Health and Wellbeing, University of Glasgow, Glasgow G12 0XH, UK.

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Claire McLeod

3Institute of Health and Wellbeing, University of Glasgow, Glasgow G12 0XH, UK.

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Ewan Ross

1Department of Brain Sciences, Imperial College London, London W12 0NN, UK.

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Amanda Heslegrave

4UK Dementia Research Institute, University College London, London WC1N 3BG, UK.

5Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.

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Henrik Zetterberg

4UK Dementia Research Institute, University College London, London WC1N 3BG, UK.

5Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.

6Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal 431 80, Sweden.

7Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal 413 45, Sweden.

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Jan Passchier

2Invicro London, London W12 0NN, UK.

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Paul M. Matthews

1Department of Brain Sciences, Imperial College London, London W12 0NN, UK.

8UK Dementia Research Institute, Imperial College London, London W12 0NN, UK.

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Roger N. Gunn

1Department of Brain Sciences, Imperial College London, London W12 0NN, UK.

2Invicro London, London W12 0NN, UK.

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Tom M. McMillan

3Institute of Health and Wellbeing, University of Glasgow, Glasgow G12 0XH, UK.

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David J. Sharp

1Department of Brain Sciences, Imperial College London, London W12 0NN, UK.

8UK Dementia Research Institute, Imperial College London, London W12 0NN, UK.

9Royal British Legion Centre for Blast Injury Studies, Imperial College London, London, UK.

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For correspondence: david.sharp@imperial.ac.uk

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In vivo detection of cerebral tau pathology in long-term survivors of traumatic brain injury

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