In vivo detection of cerebral tau pathology in long-term survivors of traumatic brain injury

Nikos Gorgoraptis; Lucia M. Li; Alex Whittington; Karl A. Zimmerman; Linda M. Maclean; Claire McLeod; Ewan Ross; Amanda Heslegrave; Henrik Zetterberg; Jan Passchier; Paul M. Matthews; Roger N. Gunn; Tom M. McMillan; David J. Sharp

doi:10.1126/scitranslmed.aaw1993

Research ArticleTraumatic Brain Injury

In vivo detection of cerebral tau pathology in long-term survivors of traumatic brain injury

View ORCID ProfileNikos Gorgoraptis¹,
Lucia M. Li¹,
View ORCID ProfileAlex Whittington¹,²,
View ORCID ProfileKarl A. Zimmerman¹,
Linda M. Maclean³,
Claire McLeod³,
View ORCID ProfileEwan Ross¹,
View ORCID ProfileAmanda Heslegrave⁴,⁵,
Henrik Zetterberg⁴,⁵,⁶,⁷,
Jan Passchier²,
View ORCID ProfilePaul M. Matthews¹,⁸,
View ORCID ProfileRoger N. Gunn¹,²,
View ORCID ProfileTom M. McMillan³ and
View ORCID ProfileDavid J. Sharp ¹,⁸,⁹,*

¹Department of Brain Sciences, Imperial College London, London W12 0NN, UK.
²Invicro London, London W12 0NN, UK.
³Institute of Health and Wellbeing, University of Glasgow, Glasgow G12 0XH, UK.
⁴UK Dementia Research Institute, University College London, London WC1N 3BG, UK.
⁵Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
⁶Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal 431 80, Sweden.
⁷Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal 413 45, Sweden.
⁸UK Dementia Research Institute, Imperial College London, London W12 0NN, UK.
⁹Royal British Legion Centre for Blast Injury Studies, Imperial College London, London, UK.

↵*Corresponding author. Email: david.sharp{at}imperial.ac.uk

See allHide authors and affiliations

Science Translational Medicine 04 Sep 2019:
Vol. 11, Issue 508, eaaw1993
DOI: 10.1126/scitranslmed.aaw1993

Nikos Gorgoraptis

1Department of Brain Sciences, Imperial College London, London W12 0NN, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Nikos Gorgoraptis

Lucia M. Li

1Department of Brain Sciences, Imperial College London, London W12 0NN, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Alex Whittington

1Department of Brain Sciences, Imperial College London, London W12 0NN, UK.

2Invicro London, London W12 0NN, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Alex Whittington

Karl A. Zimmerman

1Department of Brain Sciences, Imperial College London, London W12 0NN, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Karl A. Zimmerman

Linda M. Maclean

3Institute of Health and Wellbeing, University of Glasgow, Glasgow G12 0XH, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Claire McLeod

3Institute of Health and Wellbeing, University of Glasgow, Glasgow G12 0XH, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Ewan Ross

1Department of Brain Sciences, Imperial College London, London W12 0NN, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Ewan Ross

Amanda Heslegrave

4UK Dementia Research Institute, University College London, London WC1N 3BG, UK.

5Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Amanda Heslegrave

Henrik Zetterberg

4UK Dementia Research Institute, University College London, London WC1N 3BG, UK.

5Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.

6Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal 431 80, Sweden.

7Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal 413 45, Sweden.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jan Passchier

2Invicro London, London W12 0NN, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Paul M. Matthews

1Department of Brain Sciences, Imperial College London, London W12 0NN, UK.

8UK Dementia Research Institute, Imperial College London, London W12 0NN, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Paul M. Matthews

Roger N. Gunn

1Department of Brain Sciences, Imperial College London, London W12 0NN, UK.

2Invicro London, London W12 0NN, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Roger N. Gunn

Tom M. McMillan

3Institute of Health and Wellbeing, University of Glasgow, Glasgow G12 0XH, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Tom M. McMillan

David J. Sharp

1Department of Brain Sciences, Imperial College London, London W12 0NN, UK.

8UK Dementia Research Institute, Imperial College London, London W12 0NN, UK.

9Royal British Legion Centre for Blast Injury Studies, Imperial College London, London, UK.

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for David J. Sharp
For correspondence: david.sharp@imperial.ac.uk

Article
Figures & Data
Info & Metrics
eLetters
PDF

eLetters is an online forum for ongoing peer review. Submission of eLetters are open to all. Please read our Terms of Service before submitting your own eLetter.

Submit a Response to This Article

Compose eLetter

Title

Contents

More information about text formats

Plain text

Plain text
No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First name and middle name First or given name, e.g. 'Peter'. Last Name Your last, or family, name, e.g. 'MacMoody'. Email Your email address, e.g. higgs-boson@gmail.com Role / Occupation Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests?

Yes

Please describe the competing interests

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

No eLetters have been published for this article.

View Full Text

In vivo detection of cerebral tau pathology in long-term survivors of traumatic brain injury

Plain text

Vertical Tabs

Science Translational Medicine

Article Tools