04 September 2019
Vol 11, Issue 508

About The Cover

Cover image expansion

ONLINE COVER Nefarious Neutrophils. Hidradenitis suppurativa (HS), also known as acne inversa, is a debilitating skin condition of unknown etiology, characterized by painful nodules, sores, and scarring. Because neutrophils were identified in HS lesions previously, Byrd et al. took a closer look at the immune system's role in this devastating disease. Shown here is an image of a skin lesion from a patient with HS, stained for markers of neutrophil activity (peptidylarginine deiminase 1 in green and neutrophil extracellular traps in red). By comparing skin samples from patients and healthy subjects, the authors uncovered distinct local immune alterations. They observed neutrophil activation, B cell dysregulation, and a type I interferon signature, all of which may contribute to disease pathology. [CREDIT: BYRD ET AL./SCIENCE TRANSLATIONAL MEDICINE]