Research ArticleHIV
A vaccine-induced gene expression signature correlates with protection against SIV and HIV in multiple trials
- View ORCID ProfilePhilip K. Ehrenberg1,*,
- View ORCID ProfileShida Shangguan1,2,*,
- View ORCID ProfileBiju Issac1,2,
- View ORCID ProfileGalit Alter3,
- View ORCID ProfileAviva Geretz1,2,
- View ORCID ProfileTaisuke Izumi1,2,
- View ORCID ProfileChristopher Bryant4,
- View ORCID ProfileMichael A. Eller1,2,
- View ORCID ProfileFrank Wegmann5,
- Richard Apps6,
- View ORCID ProfileMatthew Creegan1,2,
- View ORCID ProfileDiane L. Bolton1,2,
- View ORCID ProfileRafick P. Sekaly7,
- View ORCID ProfileMerlin L. Robb1,2,
- View ORCID ProfileRobert A. Gramzinski1,
- View ORCID ProfileMaria G. Pau5,
- View ORCID ProfileHanneke Schuitemaker5,
- View ORCID ProfileDan H. Barouch3,8,
- View ORCID ProfileNelson L. Michael1,2 and
- View ORCID ProfileRasmi Thomas1,2,†
- 1U.S. Military HIV Research Program (MHRP), Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
- 2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
- 3Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
- 4EMMES Corporation, Rockville, MD 20850, USA.
- 5Janssen Vaccines and Prevention B.V., 2329 Leiden, Netherlands.
- 6Center for Human Immunology, National Institutes of Health, Bethesda, MD 20814, USA.
- 7Case Western Reserve University, Cleveland, OH 44106, USA.
- 8Center for Virology and Vaccine Research, BIDMC, Harvard Medical School, Boston, MA 02115, USA.
- ↵†Corresponding author. Email: rthomas{at}hivresearch.org
↵* These authors contributed equally to this work.
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Science Translational Medicine 28 Aug 2019:
Vol. 11, Issue 507, eaaw4236
DOI: 10.1126/scitranslmed.aaw4236
Vol. 11, Issue 507, eaaw4236
DOI: 10.1126/scitranslmed.aaw4236
Philip K. Ehrenberg
1U.S. Military HIV Research Program (MHRP), Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Shida Shangguan
1U.S. Military HIV Research Program (MHRP), Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Biju Issac
1U.S. Military HIV Research Program (MHRP), Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Galit Alter
3Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
Aviva Geretz
1U.S. Military HIV Research Program (MHRP), Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Taisuke Izumi
1U.S. Military HIV Research Program (MHRP), Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Christopher Bryant
4EMMES Corporation, Rockville, MD 20850, USA.
Michael A. Eller
1U.S. Military HIV Research Program (MHRP), Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Frank Wegmann
5Janssen Vaccines and Prevention B.V., 2329 Leiden, Netherlands.
Richard Apps
6Center for Human Immunology, National Institutes of Health, Bethesda, MD 20814, USA.
Matthew Creegan
1U.S. Military HIV Research Program (MHRP), Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Diane L. Bolton
1U.S. Military HIV Research Program (MHRP), Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Rafick P. Sekaly
7Case Western Reserve University, Cleveland, OH 44106, USA.
Merlin L. Robb
1U.S. Military HIV Research Program (MHRP), Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Robert A. Gramzinski
1U.S. Military HIV Research Program (MHRP), Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Maria G. Pau
5Janssen Vaccines and Prevention B.V., 2329 Leiden, Netherlands.
Hanneke Schuitemaker
5Janssen Vaccines and Prevention B.V., 2329 Leiden, Netherlands.
Dan H. Barouch
3Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
8Center for Virology and Vaccine Research, BIDMC, Harvard Medical School, Boston, MA 02115, USA.
Nelson L. Michael
1U.S. Military HIV Research Program (MHRP), Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
Rasmi Thomas
1U.S. Military HIV Research Program (MHRP), Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
2Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
