Research ArticleAlzheimer’s Disease

Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease

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Science Translational Medicine  28 Aug 2019:
Vol. 11, Issue 507, eaav6221
DOI: 10.1126/scitranslmed.aav6221

Article Information

vol. 11 no. 507

PubMed: 
Print ISSN: 
Online ISSN: 
History: 
  • Received for publication October 4, 2018
  • Resubmitted December 24, 2018
  • Accepted for publication April 27, 2019
  • .

Author Information

  1. Michael Ewers1,*,,
  2. Nicolai Franzmeier1,*,
  3. Marc Suárez-Calvet2,3,4,5,*,
  4. Estrella Morenas-Rodriguez2,6,
  5. Miguel Angel Araque Caballero1,
  6. Gernot Kleinberger2,7,8,
  7. Laura Piccio9,10,11,
  8. Carlos Cruchaga10,12,
  9. Yuetiva Deming10,12,
  10. Martin Dichgans1,3,7,
  11. John Q. Trojanowski13,
  12. Leslie M. Shaw14,
  13. Michael W. Weiner15,
  14. Christian Haass2,3,7,,
  15. Alzheimer’s Disease Neuroimaging Initiative
  1. 1Institute for Stroke and Dementia Research, University Hospital Munich, LMU, Munich, Germany.
  2. 2Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
  3. 3German Center for Neurodegenerative Diseases (DZNE) Munich, Munich, Germany.
  4. 4Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation. Barcelona, Catalonia, Spain.
  5. 5Department of Neurology, Hospital del Mar, Barcelona, Catalonia, Spain.
  6. 6Department of Neurology, Institut d’Investigacions Biomèdiques, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  7. 7Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.
  8. 8ISAR Bioscience GmbH, 82152 Planegg, Germany.
  9. 9Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
  10. 10Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.
  11. 11Brain and Mind Centre, University of Sydney, Sydney, Australia.
  12. 12Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
  13. 13Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  14. 14Center for Neurodegenerative Disease Research, Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  15. 15University of California at San Francisco, San Francisco, CA, USA.
  1. Corresponding author. Email: michael.ewers{at}med.uni-muenchen.de (M.E.); christian.haass{at}mail03.med.uni-muenchen.de (C.H.)
  • * These authors contributed equally to this work.

  • Present address: BarcelonaBeta Brain Research Center (BBRC), Pasqual Maragall Foundation. Barcelona, Catalonia, Spain.

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Aug 20192045043957
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Oct 2019795192165
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Dec 20199178187
Jan 202089110794
Feb 20207635752
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