28 August 2019
Vol 11, Issue 507

About The Cover

Cover image expansion

ONLINE COVER Clearing the Airways. This image shows an x-ray image of the chest of a patient with chronic obstructive pulmonary disorder (COPD). Inhaled corticosteroids are commonly prescribed for treating COPD, however, this treatment is associated with increased risk of lung infection. Singanayagam et al. examined the airway microbiome in sputum samples from patients with COPD given inhaled corticosteroids and showed increased proliferation of pathogenic bacteria. In mice, inhaled corticosteroids promoted bacterial proliferation by inhibiting the protease cathelicidin, a peptide important for innate immune defense. Boosting cathelicidin production prevented inhaled corticosteroid-induced bacterial proliferation in mice. [CREDIT: SCOTT CAMAZINE/SCIENCE SOURCE]